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학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
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논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2009.1
- 수록면
- 315 - 324 (10page)
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초록· 키워드
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Mesenchymal stem cells (MSCs) can inhibit T cell proliferation;
however, the underlying mechanisms are
not clear. In this study, we investigated the mechanisms
of the immunoregulatory activity of MSCs on T
cells. Irradiated MSCs co-cultured with either naïve or
pre-activated T cells in a mixed lymphocyte reaction
(MLR) significantly suppressed T cell proliferation in
a dose-dependent manner, irrespective of allogeneic
disparity between responders and MSCs. Transwell
assays revealed that the suppressive effect was primarily
mediated by soluble factors that induced
apoptosis. Splenocytes stimulated with alloantigen in
the presence of the MSC culture supernatant (CS) produced
a significant amount of IL-10, which was attributed
to an increase in the number of IL-10 secreting
cells, confirmed by an ELISPOT assay. The blockade
of IL-10 and IL-10 receptor interaction by anti-IL-10 or
anti-IL-10-receptor antibodies abrogated the suppressive
capacity of MSC CS, indicating that IL-10
plays a major role in the suppression of T cell
proliferation. The addition of 1-methyl-DL-tryptophan
(1-MT), an indoleamine 2,3-dioxygenase (IDO) inhibitor,
also restored the proliferative capacity of T
cells. In conclusion, we demonstrated that soluble mediators
from culture supernatant of MSCs could suppress
the proliferation of both naïve and pre-activated
T cells in which IL-10 and IDO play important roles.
목차
등록된 정보가 없습니다.
참고문헌 (23)
참고문헌 신청
Aggarwal S / 2005 / Human mesenchymal stem cells modulate allogeneic immune cell responses / Blood 105 : 1815 ~ 1822
Ayala A / 2001 / IL-10 mediation of activation-induced TH1 cell apoptosis and lymphoid dysfunction in polymicrobial sepsis / Cytokine 14 : 37 ~ 48
Beyth S / 2005 / Human mesenchymal stem cells alter antigen-presenting cell maturation and induce T-cell unresponsiveness / Blood 105 : 2214 ~ 2219
Bodaghi B / 1999 / Role of IFN-gamma-induced indoleamine 2,3 dioxygenase and inducible nitric oxide synthase in the replication of human cytomegalovirus in retinal pigment ep
Corcione A / 2006 / Human mesenchymal stem cells modulate B-cell functions / Blood 107 : 367 ~ 372
Ayala A / 2001 / IL-10 mediation of activation-induced TH1 cell apoptosis and lymphoid dysfunction in polymicrobial sepsis / Cytokine 14 : 37 ~ 48
Beyth S / 2005 / Human mesenchymal stem cells alter antigen-presenting cell maturation and induce T-cell unresponsiveness / Blood 105 : 2214 ~ 2219
Bodaghi B / 1999 / Role of IFN-gamma-induced indoleamine 2,3 dioxygenase and inducible nitric oxide synthase in the replication of human cytomegalovirus in retinal pigment ep
Corcione A / 2006 / Human mesenchymal stem cells modulate B-cell functions / Blood 107 : 367 ~ 372
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