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논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2009.1
- 수록면
- 611 - 617 (7page)
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초록· 키워드
오류제보하기
Amyotrophic lateral sclerosis (ALS) is a neurodegenerative
disease caused by the degeneration of
motor neurons. Mutations in Cu/Zn superoxide dismutase
(SOD1), including G93A, were reportedly
linked to familial ALS. SOD1 is a key antioxidant enzyme,
and is also one of the major targets for oxidative
damage in the brains of patients suffering from
Alzheimer’s disease (AD). Several lines of evidence
suggest that intracellular amyloid beta (Aβ) is associated
with the pathogenesis of AD. In this report we
demonstrate that intracellular Aβ directly interacts
with SOD1, and that this interaction decreases the enzymatic
activity of the enzyme. We observed Aβ-SOD1
aggregates in the perinuclear region of H4 cells, and
mapped the SOD1 binding region to Aβ amino acids
26-42. Interestingly, intracellular Aβ binds to the SOD1
G93A mutant with greater affinity than to wild-type
SOD1. This resulted in considerably less mutant enzymatic
activity. Our study implicates a potential role for
Aβ in the development of ALS by interacting with the
SOD1 G93A mutant.
목차
등록된 정보가 없습니다.
참고문헌 (17)
참고문헌 신청
Canevari L / 1999 / beta-Amyloid fragment 25-35 selectively decreases complex IV activity in isolated mitochondria / FEBS Lett 457 : 131 ~ 134
Chauhan V / 2006 / Oxidative stress in Alzheimer's disease / Pathophysiology 13 : 195 ~ 208
Gouras GK / 2000 / Intraneuronal Abeta42 accumulation in human brain / Am J Pathol 156 : 15 ~ 20
Higgins CM / 2003 / ALS-associated mutant SOD1G93A causes mitochondrial vacuolation by expansion of the intermembrane space and by involvement of SOD1 aggregation and peroxis
Hyun-Jung Kim / 2007 / Calcium-influx increases SOD1 aggregates via nitric oxide incultured motor neurons / Experimental and Molecular Medicine 39 (5) : 574 ~ 582
Chauhan V / 2006 / Oxidative stress in Alzheimer's disease / Pathophysiology 13 : 195 ~ 208
Gouras GK / 2000 / Intraneuronal Abeta42 accumulation in human brain / Am J Pathol 156 : 15 ~ 20
Higgins CM / 2003 / ALS-associated mutant SOD1G93A causes mitochondrial vacuolation by expansion of the intermembrane space and by involvement of SOD1 aggregation and peroxis
Hyun-Jung Kim / 2007 / Calcium-influx increases SOD1 aggregates via nitric oxide incultured motor neurons / Experimental and Molecular Medicine 39 (5) : 574 ~ 582
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대장균에서의 human SOD1과 mutant SOD1 (G93A) 단백질의 발현과 HtrA2의 기질 여부 확인에 관한 연구
생명과학회지
2006 .08
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Sphingomonas sp. KS 301의 Superoxide Dismutase 정제 및 특성
미생물학회지
2007 .06
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Sensory involvement in the SOD1-G93A mouse model of amyotrophic lateral sclerosis
Experimental and Molecular Medicine
2009 .01
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Calcium-influx increases SOD1 aggregates via nitric oxide incultured motor neurons
Experimental and Molecular Medicine
2007 .01
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발효 대두 식품의 Superoxide dismutase ( SOD ) 활성 ( Activity of Superoxide dismutase ( SOD ) by fermented soybean )
생명과학회지
2001 .12
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CHIP promotes the degradation of mutant SOD1 by reducing its interaction with VCP and S6/S6' subunits of 26S proteasome
Animal cells and systems
2010 .01
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Expressional Analysis of Superoxide Dismutase in Olive Flounder (Paralichthys olivaceus) against Viral Hemorrhagic Septicemia Virus Infection
생명과학회지
2014 .12
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팔당호 수변부 퇴적물이 수층의 산소소모에 미치는 영향
한국하천호수학회지
2000 .01
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Regulation of Genes Encoding Ni-SOD and Fe-SOD through a Metal-specific Regulator and Small RNA
한국미생물학회 학술대회논문집
2013 .05
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Characteristics of the Diamond Thin Film as the SOD Structure
한국진공학회 학술발표회초록집
1999 .07
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염 환경하에서 근대(Beta vulgaris var. cicla)의 생장과 항산화효소(SOD, APX, GR)의 활성변화
생명과학회지
2003 .10
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Superoxide dismutase의 활성차이에 따른 식물세포의 paraquat에 대한 반응과 핵 DNA 손상 검정
생명과학회지
2004 .08
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Construction of Gene-Specific Primers for Various Antioxidant Isoenzyme Genes and Their Expressions in Rice (Oryza sativa L.) Seedlings Obtained from Gamma-irradiated Seeds
Journal of photoscience : an international journal officail organ of the korean society of photoscience
2004 .01
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신기능성 SOD 대두발효식품의 개발
한국생명과학회 학술발표회
2001 .01
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Motor neurons derived from ALS-related mouse iPS cells recapitulate pathological features of ALS
Experimental and Molecular Medicine
2016 .01
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백두산 자생참돌꽃의 생육과 이용 II. 유식물의 부위별 superoxide dismutase 활성
환경생물
2008 .01
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홍모기(Cufexpipienspoiffens)의 난성숙 과정중 Superoxide dismutase의 활성
동물학회지
1994 .01
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Differential regulation of inducible nitric oxide synthase and cyclooxygenase-2 expression by superoxide dismutase in lipopolysaccharide stimulated RAW 264.7 cells
Experimental and Molecular Medicine
2009 .01
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Klebsiella의 SOD 활성과 대식세포내 생존과의 상관성
The Journal of the Korean Society for Microbiology
1995 .06
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Photochemical Damage and Responses of Antioxidant Enzymes in Rice Leaves Induced to Light-Chilling
생명과학회지
2009 .04
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