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논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2010.1
- 수록면
- 69 - 79 (11page)
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This study was designed to investigate the effects of cAMP on immune regulation and apoptosis during acute rat cardiac allograft rejection. We found that the production of immune markers such as inflammatory cytokines (IL-1β, IL-6, and TNF-α), iNOS expression,and nitric oxide (NO) production, was significantly increased in the blood and transplanted hearts of allograft recipients, but not of isograft controls. These increases were effectively suppressed by the administration of the membrane permeable cAMP analog dibutyryl cAMP (db-cAMP). Administration of db-cAMP reduced allograft-induced elevation of several biochemical markers, such as adhesion molecule expression,iron-nitrosyl complex formation, caspase-3activation, and apoptotic DNA fragmentation in an animal model. Furthermore, treatment of allograft recipients with db-cAMP prolonged median graft survival to 11 days compared with a median graft survival time of 8 days in saline-treated allograft recipients. These results suggest that db-cAMP exerts a beneficial effect on murine cardiac allograft survival by modulating allogeneic immune response and cytotoxicity.
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참고문헌 (22)
참고문헌 신청
Balligand JL / 1993 / Abnormal contractile function due to induction of nitric oxide synthesis in rat cardiac myocytes follows exposure to activated macrophage-conditioned me
Cai B / 1995 / Effects of immunosuppressive therapy on expression of inducible nitric oxide synthase (iNOS) during cardiac allograft rejection / Int J Cardiol 50 : 243 ~ 251
Demetris AJ / 1997 / Obliterative arteriopathy and Quilty lesions: leukocyte trafficking, microchimerism and the immunolymphatic theory of chronic rejection / Am J Pathol 150
Furukawa Y / 1996 / Immunomodulation by an adenylate cyclase activator, NKH477, in vivo and in vitro / Clin Immunol Immunopathol 79 : 25 ~ 35
Hanna AK / 1993 / Reversible contractile dysfunction in reversible experimental cardiac allograft rejection: alterations in the beta-receptor-stimulated adenylylcyclase pathw
Cai B / 1995 / Effects of immunosuppressive therapy on expression of inducible nitric oxide synthase (iNOS) during cardiac allograft rejection / Int J Cardiol 50 : 243 ~ 251
Demetris AJ / 1997 / Obliterative arteriopathy and Quilty lesions: leukocyte trafficking, microchimerism and the immunolymphatic theory of chronic rejection / Am J Pathol 150
Furukawa Y / 1996 / Immunomodulation by an adenylate cyclase activator, NKH477, in vivo and in vitro / Clin Immunol Immunopathol 79 : 25 ~ 35
Hanna AK / 1993 / Reversible contractile dysfunction in reversible experimental cardiac allograft rejection: alterations in the beta-receptor-stimulated adenylylcyclase pathw
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