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학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
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논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2009.1
- 수록면
- 707 - 716 (10page)
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In addition to CD4+CD25+Foxp3+ regulatory T (Treg) cells which protect against autoimmune tissue injury, IL-17-producing CD4+ T (Th17) cells have been recently described and shown to play a crucial role in autoimmune injury. It appears that there is a reciprocal developmental pathway between Th17 and Treg cells.
Although IL-17 is known to be associated with allograft rejection, the cellular source of IL-17 and the nature of Th17 in the context of allograft rejection remain unknown. In the current study, the dynamics of Treg and IL-17-producing cells after syngeneic and allogeneic transplantation were examined using a wild-type murine cardiac transplantation model. Ly6G+ cells were found to produce IL-17 during the early postoperative period and CD8+ as well as CD4+ T cells were also found to produce IL-17 during alloimmune response.
Graft-infiltrating Ly6G+, CD4+, and even CD8+ cells were found to express IL-17 highly compared to those in spleen. Although the frequencies of Th17 and Treg were found to gradually increase in both syngeneic and allogeneic recipients, Th17/Treg ratios were significantly higher in recipients with allograft rejection than in syngeneic recipients. In conclusion, IL-17 is produced by neutrophils during the early postoperative period and subsequently by Th17 and CD8+ T cells during allograft rejection. Th17/Treg imbalance is associated with the development of allograft rejection. This study would provide basic information on Th17 biology for future investigation in the field of transplantation.
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참고문헌 (24)
참고문헌 신청
Abbas AK / 1996 / Functional diversity of helper T lymphocytes / Nature 383 : 787 ~ 793
Aggarwal S / 2003 / Interleukin-23 promotes a distinct CD4 T cell activation state characterized by the production of interleukin-17 / J Biol Chem 278 : 1910 ~ 1914
Amadi-Obi A / 2007 / Th17 cells contribute to uveitis and scleritis and are expanded by IL-2 and inhibited by IL-27/STAT1 / Nat Med 13 : 711 ~ 718
Benghiat FS / 2008 / IL-17 production elicited by allo-major histocompatibility complex class II recognition depends on CD25posCD4pos T cells / Transplantation 85 : 943 ~ 949
Bettelli E / 2006 / Reciprocal developmental pathways for the generation of pathogenic effector Th17 and regulatory T cells / Nature 441 : 235 ~ 238
Aggarwal S / 2003 / Interleukin-23 promotes a distinct CD4 T cell activation state characterized by the production of interleukin-17 / J Biol Chem 278 : 1910 ~ 1914
Amadi-Obi A / 2007 / Th17 cells contribute to uveitis and scleritis and are expanded by IL-2 and inhibited by IL-27/STAT1 / Nat Med 13 : 711 ~ 718
Benghiat FS / 2008 / IL-17 production elicited by allo-major histocompatibility complex class II recognition depends on CD25posCD4pos T cells / Transplantation 85 : 943 ~ 949
Bettelli E / 2006 / Reciprocal developmental pathways for the generation of pathogenic effector Th17 and regulatory T cells / Nature 441 : 235 ~ 238
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