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논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2010.1
- 수록면
- 565 - 573 (9page)
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초록· 키워드
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Rheumatoid arthritis (RA) is a chronic, inflammatory autoimmune disorder that causes the immune system to attack the joints. Transforming growth factor-β1(TGF-β1) is a secreted protein that promotes differentiation of synovial fibroblasts to α-smooth muscle actin (α-SMA)-positive myofibroblasts to repair the damaged joints. Synovial fluid from patients with RA (RA-SF) induced expression of α-SMA in human adipose tissue-derived mesenchymal stem cells (hASCs).
RA-SF-induced α-SMA expression was abrogated by immunodepletion of TGF-β1 from RA-SF with anti-TGF-β1 antibody. Furthermore, pretreatment of hASCs with the TGF-β type I receptor inhibitor SB431542 or lentiviral small hairpin RNA-mediated silencing of TGF-β type I receptor expression in hASCs blocked RA-SF-induced α-SMA expression. Small interfering RNA-mediated silencing of Smad2 or adenoviral overexpression of Smad7 (an inhibitory Smad isoform) completely inhibited RA-SF-stimulated α-SMA expression. These results suggest that TGF-β1plays a pivotal role in RA-SF-induced differentiation of hASCs to α-SMA-positive cells.
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등록된 정보가 없습니다.
참고문헌 (23)
참고문헌 신청
Attisano L / 2000 / Smads as transcriptional co-modulators / Curr Opin Cell Biol 12 : 235 ~ 243
Barry FP / 2004 / Mesenchymal stem cells: clinical applications and biological characterization / Int J Biochem Cell Biol 36 : 658 ~ 584
Bouffi C / 2009 / Multipotent mesenchymal stromal cells and rheumatoid arthritis: risk or benefit? / Rheumatology 48 : 1185 ~ 1189
Buckley CD / 2003 / Michael Mason prize essay 2003. Why do leucocytes accumulate within chronically inflamed joints? / Rheumatology 42 : 1433 ~ 1444
De Wever O / 2008 / Stromal myofibroblasts are drivers of invasive cancer growth / Int J Cancer 123 : 2229 ~ 2238
Barry FP / 2004 / Mesenchymal stem cells: clinical applications and biological characterization / Int J Biochem Cell Biol 36 : 658 ~ 584
Bouffi C / 2009 / Multipotent mesenchymal stromal cells and rheumatoid arthritis: risk or benefit? / Rheumatology 48 : 1185 ~ 1189
Buckley CD / 2003 / Michael Mason prize essay 2003. Why do leucocytes accumulate within chronically inflamed joints? / Rheumatology 42 : 1433 ~ 1444
De Wever O / 2008 / Stromal myofibroblasts are drivers of invasive cancer growth / Int J Cancer 123 : 2229 ~ 2238
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