지원사업
학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
커뮤니티
연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2010.1
- 수록면
- 606 - 613 (8page)
이용수
초록· 키워드
오류제보하기
Angiogenesis is a multi-step process that involves the activation, proliferation, and migration of endothelial cells. We have recently shown that TGF-β1 can induce mouse macrophages to produce VEGF, a potent angiogenic factor. In the present study, we explored whether TGF-β1 has a similar effect on mouse dendritic cells.
First, we show that under hypoxic conditions, TGF-β1induced the expression of VEGF transcripts in bone marrow-derived dendritic cells. Overexpression of Smad3/4 further augmented TGF-β1-induced VEGF transcription, while overexpression of DN-Smad3 decreased VEGF transcription in DC2.4 cells, a mouse dendritic cell line. We also show that TGF-β1 and Smads are involved in the induction of VEGF protein secretion. Interestingly, under the same conditions,the expression of VEGF receptor 1 (Flt-1) was also elevated at both the transcriptional and protein levels.
Additionally, we found that the TGF-β1-induced VEGF secretion in activated DC2.4 cells has wound-healing properties. Finally, Smad7 and Smurf1 negatively regulated the TGF-β1-induced and Smad3/4-mediated VEGF expression. Taken together, these results indicate that TGF-β1 can enhance the expression of VEGF and Flt-1 through the typical Smad pathway in mouse dendritic cells.
목차
등록된 정보가 없습니다.
참고문헌 (23)
참고문헌 신청
Bao P / 2009 / The role of vascular endothelial growth factor in wound healing / J Surg Res 153 : 347 ~ 358
Breier G / 2002 / Transforming growth factor-beta and Ras regulate the VEGF/VEGF-receptor system during tumor angiogenesis / Int J Cancer 97 : 142 ~ 148
Byrne AM / 2005 / Angiogenic and cell survival functions of vascular endothelial growth factor (VEGF) / J Cell Mol Med 9 : 777 ~ 794
Carmeliet P / 2005 / VEGF as a key mediator of angiogenesis in cancer / Oncology 69 (3) : 4 ~ 10
Ebisawa T / 2001 / Smurf1 interacts with transforming growth factor-beta type I receptor through Smad7 and induces receptor degradation / J Biol Chem 276 : 12477 ~ 12480
Breier G / 2002 / Transforming growth factor-beta and Ras regulate the VEGF/VEGF-receptor system during tumor angiogenesis / Int J Cancer 97 : 142 ~ 148
Byrne AM / 2005 / Angiogenic and cell survival functions of vascular endothelial growth factor (VEGF) / J Cell Mol Med 9 : 777 ~ 794
Carmeliet P / 2005 / VEGF as a key mediator of angiogenesis in cancer / Oncology 69 (3) : 4 ~ 10
Ebisawa T / 2001 / Smurf1 interacts with transforming growth factor-beta type I receptor through Smad7 and induces receptor degradation / J Biol Chem 276 : 12477 ~ 12480
함께 읽어보면 좋을 논문
논문 유사도에 따라 DBpia 가 추천하는 논문입니다. 함께 보면 좋을 연관 논문을 확인해보세요!
-
TGF-β1 induces VEGF expression in human granulosa-lutein cells: a potential mechanism for the pathogenesis of ovarian hyperstimulation syndrome
Experimental and Molecular Medicine
2020 .01
-
Etoposide-induced Smad6 expression is required for the G1 toS phase transition of the cell cycle in CMT-93 mouse intestinalepithelial cells
Experimental and Molecular Medicine
2008 .01
-
A serum-stable branched dimeric anti-VEGF peptide blocks tumor growth via anti-angiogenic activity
Experimental and Molecular Medicine
2010 .01
-
An antioxidant modulates expression of receptor activator of NF-κB in asthma
Experimental and Molecular Medicine
2006 .01
-
EpH4 세포에서 TGF-β에 의한 세포사멸시 Smad 단백질에 의존한 Gadd45b 유전자의 발현 변화
생명과학회지
2008 .04
-
Kinetics and Biological Function of Transforming Growth Factor-β Isoformsin Bovine and Human Colostrum
Journal of Microbiology and Biotechnology
2004 .01
-
The discovery of placenta growth factor and its biological activity
Experimental and Molecular Medicine
2012 .01
-
Expression and Activation of Transforming Growth Factor-Beta 2 in Cultured Bone Cells
Korean journal of biological sciences
2000 .01
-
TGF-β1-induced PINCH-1-ILK-α-parvin complex formationregulates mesangial cell proliferation and hypertrophy
Experimental and Molecular Medicine
2007 .01
-
Synovial fluid of patients with rheumatoid arthritis induces α-smooth muscle actin in human adipose tissue-derived mesenchymal stem cells through a TGF-β1-dependent mechanism
Experimental and Molecular Medicine
2010 .01
-
Smad4 controls bone homeostasis through regulation of osteoblast/osteocyte viability
Experimental and Molecular Medicine
2016 .01
-
티모신베타4에의한 선모충(Trichinella spiralis) 감염의 혈관신생 유도 기작
생명과학회지
2013 .09
-
Combined blockade of HER2 and VEGF exerts greater growth inhibition of HER2-overexpressing gastric cancer xenografts than individual blockade
Experimental and Molecular Medicine
2013 .01
-
TGF-β1 suppresses CCL3/4 expression through the ERK signaling pathway and inhibits intervertebral disc degeneration and inflammation-related pain in a rat model
Experimental and Molecular Medicine
2017 .01
-
Angiotensin II receptor blocker attenuates overexpression of vascular endothelial growth factor in diabetic podocytes
Experimental and Molecular Medicine
2004 .01
-
Tissue microarray를 이용한 사이모신 베타4(Thymosin β4)와 vascular endothelial cell growth factor (VEGF)의 정상 인간 조직 발현 양상 연구
생명과학회지
2009 .12
-
TGF-β3는 마우스 IgA, IgG2b 항체의 선택적 유도작용
미생물학회지
1999 .06
-
Effective glycemic control achieved by transplanting non-viral cationic liposome-mediated VEGF-transfected islets in streptozotocin-induced diabetic mice
Experimental and Molecular Medicine
2005 .01
-
Regulation of anti-inflammatory cytokines IL-10 and TGF-b in mouse dendritic cells through treatment with Clonorchis sinensis crude antigen
Experimental and Molecular Medicine
2014 .01
이 논문의 저자 정보
최근 본 자료
댓글(0)
0