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논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2002.1
- 수록면
- 273 - 277 (5page)
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Peroxiredoxin II (Prx II) is known not only to protectcells from oxidative damage caused by hydrogen per-oxide (H2O2), but also to endow cancer cells with resis-tance to both H 2O2 and cisplatin and to grant themradioresistance. In this study, we examined whetherPrx II antisense could enhance cisplatin-induced celldeath. When gastric cancer cells were transfected withvarious concentrations of Prx II antisense plasmid,pPrxII/AS, and then treated with the same concentra-tions of cisplatin, Prx II antisense enhanced cisplatin-induced cell death. The combination index (CI) at alldoses of the combination was below 1, indicating thatPrx II antisense sensitized cisplatin-induced cell death.This synergism was also observed in the cells trans-fected with a Prx II antisense oligomer. Our presentresults, therefore, suggest that Prx II antisense wouldbe a very good sensitizer for cisplatin, and that Prx II asa target for chemosensitizers constitutes a promisingavenue for future research.
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