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학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
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논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2008.1
- 수록면
- 43 - 51 (9page)
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The inhibitory Smad6 and Smad7 are responsible for
cross-talk between TGF-β/bone morphogenic protein
(BMP) signaling and other cellular signaling pathways,
as well as negative feedback on their own signaling
functions. Although inhibitory Smads are induced by
various stimuli, little is known about the stimuli that increase
Smad6 transcription, in contrast to Smad7.
Here we demonstrate that etoposide, which induces
double strand breaks during DNA replication, significantly
up-regulates the transcription of the Smad6
gene in CMT-93 mouse intestinal cells by increasing
specific DNA binding proteins. In addition, endogenous
inhibition of the Smad6 gene by RNAi interference
led to transient accumulation of G1 phase cells
and reduction in incorporation of bromodeoxyuridine
(BrdU). These findings strongly suggest that Smad6
plays a distinct role in the signaling of etoposide-
induced DNA damage.
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참고문헌 (23)
참고문헌 신청
Bitzer M / 2000 / A mechanism of suppression of TGF-beta/SMAD signaling by NF-kappa B/RelA / Genes Dev 14 : 187 ~ 97
Blass M / 2002 / Tyrosine phosphorylation of protein kinase Cdelta is essential for its apoptotic effect in response to etoposide / Mol Cell Biol 22 : 182 ~ 95
Choi KC / 2006 / Smad6 negatively regulates interleukin 1-receptor-toll-like receptor signaling through direct interaction with the adaptor Pellino-1 / Nat Immunol 7 : 1057 ~
Clifford B / 2003 / G2 arrest in response to topoisomerase II inhibitors: the role of p53 / Cancer Res 63 : 4074 ~ 81
Ebisawa T / 2001 / Smurf1 interacts with transforming growth factor-beta type I receptor through Smad7 and induces receptor degradation / J Biol Chem 276 : 12477 ~ 80
Blass M / 2002 / Tyrosine phosphorylation of protein kinase Cdelta is essential for its apoptotic effect in response to etoposide / Mol Cell Biol 22 : 182 ~ 95
Choi KC / 2006 / Smad6 negatively regulates interleukin 1-receptor-toll-like receptor signaling through direct interaction with the adaptor Pellino-1 / Nat Immunol 7 : 1057 ~
Clifford B / 2003 / G2 arrest in response to topoisomerase II inhibitors: the role of p53 / Cancer Res 63 : 4074 ~ 81
Ebisawa T / 2001 / Smurf1 interacts with transforming growth factor-beta type I receptor through Smad7 and induces receptor degradation / J Biol Chem 276 : 12477 ~ 80
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