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논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2009.1
- 수록면
- 397 - 405 (9page)
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초록· 키워드
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Peroxisome proliferator-activated receptor α (PPARα)
activation in rodents is thought to improve insulin sensitivity
by decreasing ectopic lipids in non-adipose
tissues. Fenofibrate, a lipid-modifying agent that acts
as a PPARα agonist, may prevent adipocyte hypertrophy
and insulin resistance by increasing intracellular
lipolysis from adipose tissue. Consistent with
this hypothesis, fenofibrate decreased visceral fat
mass and adipocyte size in high fat diet-fed obese mice,
and concomitantly increased the expression of PPARα
target genes involved in fatty acid β-oxidation in both
epididymal adipose tissue and differentiated 3T3-L1
adipocytes. However, mRNA levels of adipose marker
genes, such as leptin and TNFα, were decreased in epididymal
adipose tissue by fenofibrate treatment.
Fenofibrate not only reduced circulating levels of free
fatty acids and triglycerides, but also normalized hyperinsulinemia
and hyperglycemia in obese mice.
Blood glucose levels of fenofibrate-treated mice were
significantly reduced during intraperitoneal glucose
tolerance test compared with obese controls. These results
suggest that fenofibrate-induced fatty acid
β-oxidation in visceral adipose tissue may be one of the
major factors leading to decreased adipocyte size and
improved insulin sensitivity.
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등록된 정보가 없습니다.
참고문헌 (24)
참고문헌 신청
Ahima RS / 2006 / Adipose tissue as an endocrine organ / Obesity 14 (5) : 242S ~ 249S
Akiyama TE / 2001 / Peroxisome proliferatoractivated receptor-alpha regulates lipid homeostasis, but is not associated with obesity: studies with congenic mouse lines / J Bio
Boden G / 1994 / Mechanisms of fatty acid-induced inhibition of glucose uptake / J Clin Invest 93 : 2438 ~ 2446
Boden G / 1997 / Role of fatty acids in the pathogenesis of insulin resistance and NIDDM / Diabetes 46 : 3 ~ 10
Boden G / 2005 / Free fatty acids and insulin secretion in humans / Curr Diab Rep 5 : 167 ~ 170
Akiyama TE / 2001 / Peroxisome proliferatoractivated receptor-alpha regulates lipid homeostasis, but is not associated with obesity: studies with congenic mouse lines / J Bio
Boden G / 1994 / Mechanisms of fatty acid-induced inhibition of glucose uptake / J Clin Invest 93 : 2438 ~ 2446
Boden G / 1997 / Role of fatty acids in the pathogenesis of insulin resistance and NIDDM / Diabetes 46 : 3 ~ 10
Boden G / 2005 / Free fatty acids and insulin secretion in humans / Curr Diab Rep 5 : 167 ~ 170
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