지원사업
학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
커뮤니티
연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2017.1
- 수록면
- 1 - 11 (11page)
이용수
초록· 키워드
오류제보하기
Tumor necrosis factor alpha (TNFα)-induced angiogenesis plays important roles in the progression of various diseases, including cancer, wet age-related macular degeneration, and rheumatoid arthritis. However, the relevance and role of vascular cell adhesion molecule-1 (VCAM-1) in angiogenesis have not yet been clearly elucidated. In this study, VCAM-1 knockdown shows VCAM-1 involvement in TNFα-induced angiogenesis. Through competitive blocking experiments with VCAM-1 Ig-like domain 6 (VCAM-1-D6) protein, we identified VCAM-1-D6 as a key domain regulating TNFα-induced vascular tube formation. We demonstrated that a monoclonal antibody specific to VCAM-1-D6 suppressed TNFα-induced endothelial cell migration and tube formation and TNFα-induced vessel sprouting in rat aortas. We also found that the antibody insignificantly affected endothelial cell viability, morphology and activation. Finally, the antibody specifically blocked VCAM-1-mediated cell–cell contacts by directly inhibiting VCAM-1-D6-mediated interaction between VCAM-1 molecules. These findings suggest that VCAM-1-D6 may be a potential novel therapeutic target in TNFα-induced angiogenesis and that antibody-based modulation of VCAM-1-D6 may be an effective strategy to suppress TNFα-induced angiogenesis.
목차
등록된 정보가 없습니다.
참고문헌 (23)
참고문헌 신청
Aref AA / 2015 / Current management of glaucoma and vascular occlusive disease / Curr Opin Ophthalmol 27 : 140 ~ 145
Carlos TM / 1990 / Vascular cell adhesion molecule-1 mediates lymphocyte adherence to cytokine-activated cultured human endothelial cells / Blood 76 : 965 ~ 970
Chong V / 2015 / Ranibizumab for the treatment of wet AMD : a summary of realworld studies / Eye(Lond) 30 : 270 ~ 286
DeBusk LM / 2003 / Tie2receptor tyrosine kinase, a major mediator of tumor necrosis factor alphainduced angiogenesis in rheumatoid arthritis / Arthritis Rheum 48 : 2461 ~ 247
Elshabrawy HA / 2015 / The pathogenic role of angiogenesis in rheumatoid arthritis / Angiogenesis 18 : 433 ~ 448
Carlos TM / 1990 / Vascular cell adhesion molecule-1 mediates lymphocyte adherence to cytokine-activated cultured human endothelial cells / Blood 76 : 965 ~ 970
Chong V / 2015 / Ranibizumab for the treatment of wet AMD : a summary of realworld studies / Eye(Lond) 30 : 270 ~ 286
DeBusk LM / 2003 / Tie2receptor tyrosine kinase, a major mediator of tumor necrosis factor alphainduced angiogenesis in rheumatoid arthritis / Arthritis Rheum 48 : 2461 ~ 247
Elshabrawy HA / 2015 / The pathogenic role of angiogenesis in rheumatoid arthritis / Angiogenesis 18 : 433 ~ 448
함께 읽어보면 좋을 논문
논문 유사도에 따라 DBpia 가 추천하는 논문입니다. 함께 보면 좋을 연관 논문을 확인해보세요!
-
Development of variable current application model (VCAM) for optimizing the flow stress through the inverse analysis method
한국소성가공학회 학술대회 논문집
2022 .05
-
Therapeutic Effects of Groan Tea Seed Saponins in Amelioration of Cancer by Inhibition of Inflammation and Angiogenesis and Exertion of Cytotoxic Activities in Cancer Cells
한국생물공학회 학술대회
2022 .09
-
Highly Sensitive Detection of TNF-α in a Fluidic Channel via Surface-enhanced Raman Spectroscopy
한국생물공학회 학술대회
2021 .10
-
An Internalizing Antibody Targeting of Cell Surface GRP94 Effectively Suppresses Tumor Angiogenesis of Colorectal Cancer
한국생물공학회 학술대회
2022 .09
-
M. aeruginosa Extracted Crude Microcystins Inhibits lipid Accumulation and Angiogenesis by Suppressing Angiogenesis and Adipogenesis Promoting Signaling Molecules in HUVECs and 3T3-L1 cells
한국생물공학회 학술대회
2018 .04
-
Regulation of retinal angiogenesis by phospholipase C-β3 signaling pathway
Experimental and Molecular Medicine
2016 .01
-
A Study on Trophoblast Invasion in Angiogenesis Induced Endothelial Cell
한국생물공학회 학술대회
2022 .09
-
CLEC4a as a novel therapeutic target in angiogenesis: A new challenge with antibody-based targeting of VEGF
한국생물공학회 학술대회
2017 .10
-
세포 분리배양을 통한 혈관신생 분석이 가능한 미세유체 기반 고효율 미세유체 플랫폼 개발
대한기계학회 춘추학술대회
2021 .04
-
Delivery of a Spheroids-incorporated Cell Sheet Enhancing Angiogenesis and M2 Polarization for Wound Healing
한국생물공학회 학술대회
2022 .04
-
2,3-Dimethoxy-2′-hydroxychalcone ameliorates TNF-α-induced ICAM-1 expression and subsequent monocyte adhesiveness via NF-kappaB inhibition and HO-1 induction in HaCaT cells
BMB Reports
2016 .01
-
Loss of phospholipase D2 impairs VEGF-induced angiogenesis
BMB Reports
2016 .01
-
Endothelial miR-26a regulates VEGF-Nogo-B receptor-mediated angiogenesis
BMB Reports
2017 .07
-
NF-κB-dependent miR-31/155 biogenesis is essential for TNF-α-induced impairment of endothelial progenitor cell function
Experimental and Molecular Medicine
2020 .08
-
6-sialyllactose ameliorates dihydrotestosterone-induced benign prostatic hyperplasia through suppressing VEGF-mediated angiogenesis
BMB Reports
2019 .01
-
Flow goes forward and cells step backward: endothelial migration
Experimental and Molecular Medicine
2022 .06
-
Fabrication of Three-Dimensional Vascular Network with Geometrical Regulation of Angiogenesis by Using 3D Bioprinting
한국정밀공학회 학술발표대회 논문집
2018 .10
-
Comparative study on in vitro potency test methods for the heat-treated monoclonal antibody drug
한국생물공학회 학술대회
2019 .04
이 논문의 저자 정보
최근 본 자료
댓글(0)
0