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논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2016.1
- 수록면
- 57 - 62 (6page)
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이 논문의 연구 히스토리 (2)
2016
2,3-dimethoxy-2′-hydroxychalcone ameliorates TNF-α-induced ICAM-1 expression and subsequent monocyte adhesiveness via NFkappaB inhibition and HO-1 induction in HaCaT cells
김혜진
Department of Biomedical Science Major in Biomedical Science
2016.01
학위논문
2,3-Dimethoxy-2′-hydroxychalcone ameliorates TNF-α-induced ICAM-1 expression and subsequent monocyte adhesiveness via NF-kappaB inhibition and HO-1 induction in HaCaT cells
김혜진
,
윤기수
,
안수연
외 3명
BMB Reports
2016.01
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Up-regulation of adhesion molecules plays an important role in the infiltration of leukocytes into the skin during the development of various inflammatory skin diseases, such as atopic dermatitis. In this study, we investigated the modulatory effects of 2,3-dimethoxy-2′-hydroxychalcone (DMHC) on tumor necrosis factor (TNF)-α-induced intercellular adhesion molecule-1 (ICAM-1) expression and monocyte adhesiveness, as well as the molecular mechanisms underlying its action in the HaCaT human keratinocyte cell line.
Pre-treating HaCaT cells with DMHC significantly suppressed TNF-α-induced ICAM-1 expression and subsequent monocyte adhesiveness. DMHC inhibited TNF-α-induced activation of NF-κB. In addition, DMHC induced HO-1 expression as well as NRF2 activation.
Furthermore, HO-1 knockdown using siRNA reversed the inhibitory effect of DMHC on TNF-α-induced ICAM-1 expression and adhesion of monocytes to keratinocytes. These results suggest that DMHC may inhibit TNF-α-induced ICAM-1 expression and adhesion of monocytes to keratinocytes by suppressing the signaling cascades leading to NF-κB activation and inducing HO-1 expression in keratinocytes.
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참고문헌 (24)
참고문헌 신청
Gröne A / 2002 / Keratinocytes, cytokines / Vet Immunol Immunopathol 88:1~12
Dustin ML / 1988 / Adhesion of T lymphoblasts to epidermal keratinocytes is regulated by interferon gamma, is mediated by intercellular adhesion molecule 1(ICAM-1) / J Exp Med 167:1323~1340
Trefzer U / 1991 / 55-kd tumor necrosis factor receptor is expressed by human keratinocytes, plays a pivotal role in regulation of human keratinocyte ICAM-1 expression / J Invest Dermatol 97:911~916
Albanesi C / 2005 / Keratinocytes in inflammatory skin diseases / Curr Drug Targets Inflamm Allergy 4:329~334
Griffiths CE / 1989 / Characterization of intercellular adhesion molecule-1, HLA-DR expression in normal, inflamed skin: modulation by recombinant gamma interferon, tumor necrosis factor / J Am Acad Dermatol 20:617~629
Dustin ML / 1988 / Adhesion of T lymphoblasts to epidermal keratinocytes is regulated by interferon gamma, is mediated by intercellular adhesion molecule 1(ICAM-1) / J Exp Med 167:1323~1340
Trefzer U / 1991 / 55-kd tumor necrosis factor receptor is expressed by human keratinocytes, plays a pivotal role in regulation of human keratinocyte ICAM-1 expression / J Invest Dermatol 97:911~916
Albanesi C / 2005 / Keratinocytes in inflammatory skin diseases / Curr Drug Targets Inflamm Allergy 4:329~334
Griffiths CE / 1989 / Characterization of intercellular adhesion molecule-1, HLA-DR expression in normal, inflamed skin: modulation by recombinant gamma interferon, tumor necrosis factor / J Am Acad Dermatol 20:617~629
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