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논문 기본 정보
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- 학술저널
- 저자정보
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- 2015.1
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The long-term storage of memory requires the finely tuned coordination of intracellular signaling with the transcriptional, translational and epigenetic regulations of gene expression. Among the epigenetic mechanisms, however, we know relatively little about the involvement of chromatin remodeling-dependent control of gene expression in cognitive brain functions, compared with our knowledge of other such mechanisms (for example, histone modifications and DNA methylation). A few recent studies have implicated the Brm/Brg-associated factor (BAF) chromatin-remodeling complex, a mammalian homolog of the yeast Swi/Snf complex, in neuronal structural/functional plasticity and memory formation. The BAF complex was previously known to have a critical role in neurodevelopment, but these recent findings indicate that it also contributes to both cognitive functions in the adult brain and human mental disorders characterized by intellectual disability. In this review, we provide a brief overview of the BAF complexes, introduce recent research findings that link their functions to memory formation, and speculate on the yet-unknown molecular mechanisms that may be relevant to these processes.
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참고문헌 (25)
참고문헌 신청
Ambasudhan R / 2011 / Direct reprogramming of adult human fibroblasts to functional neurons under defined conditions / Cell Stem Cell 9 : 113 ~ 118
Guan J-S / 2013 / HDAC2 negatively regulates memory formation and synaptic plasticity / Nature 459 : 55 ~ 60
Ho L / 2009 / An embryonic stem cell chromatin remodeling complex, esBAF, is an essential component of the core pluripotency transcriptional network / Proc Natl Acad Sci USA
Ho L / 2009 / An embryonic stem cell chromatin remodeling complex, esBAF, is essential for embryonic stem cell self-renewal and pluripotency / Proc Natl Acad Sci USA 106 : 5
Ho L / 2010 / Chromatin remodelling during development / Nature 463 : 474 ~ 484
Guan J-S / 2013 / HDAC2 negatively regulates memory formation and synaptic plasticity / Nature 459 : 55 ~ 60
Ho L / 2009 / An embryonic stem cell chromatin remodeling complex, esBAF, is an essential component of the core pluripotency transcriptional network / Proc Natl Acad Sci USA
Ho L / 2009 / An embryonic stem cell chromatin remodeling complex, esBAF, is essential for embryonic stem cell self-renewal and pluripotency / Proc Natl Acad Sci USA 106 : 5
Ho L / 2010 / Chromatin remodelling during development / Nature 463 : 474 ~ 484
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