지원사업
학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
커뮤니티
연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2024.2
- 수록면
- 251 - 263 (13page)
- DOI
- 10.1038/s12276-023-01145-3
이용수
초록· 키워드
오류제보하기
H3.3, the most common replacement variant for histone H3, has emerged as an important player in chromatin dynamics for controlling gene expression and genome integrity. While replicative variants H3.1 and H3.2 are primarily incorporated into nucleosomes during DNA synthesis, H3.3 is under the control of H3.3-specific histone chaperones for spatiotemporal incorporation throughout the cell cycle. Over the years, there has been progress in understanding the mechanisms by which H3.3 affects domain structure and function. Furthermore, H3.3 distribution and relative abundance profoundly impact cellular identity and plasticity during normal development and pathogenesis. Recurrent mutations in H3.3 and its chaperones have been identified in neoplastic transformation and developmental disorders, providing new insights into chromatin biology and disease. Here, we review recent findings emphasizing how two distinct histone chaperones, HIRA and DAXX, take part in the spatial and temporal distribution of H3.3 in different chromatin domains and ultimately achieve dynamic control of chromatin organization and function. Elucidating the H3.3 deposition pathways from the available histone pool will open new avenues for understanding the mechanisms by which H3.3 epigenetically regulates gene expression and its impact on cellular integrity and pathogenesis.
목차
등록된 정보가 없습니다.
참고문헌 (0)
참고문헌 신청함께 읽어보면 좋을 논문
논문 유사도에 따라 DBpia 가 추천하는 논문입니다. 함께 보면 좋을 연관 논문을 확인해보세요!
-
Histone tail cleavage as a novel epigenetic regulatory mechanism for gene expression
BMB Reports
2018 .01
-
Identification of small molecules that inhibit the histone chaperone Asf1 and its chromatin function
BMB Reports
2015 .01
-
A short guide to histone deacetylases including recent progress on class II enzymes
Experimental and Molecular Medicine
2020 .02
-
Differential regulation of the histone chaperone HIRA during muscle cell differentiation by a phosphorylation switch
Experimental and Molecular Medicine
2016 .01
-
플라즈몬 나노 입자의 광학적 특성을 활용한 세포 노화 측정에 대한 수치적 연구
대한기계학회 춘추학술대회
2021 .08
-
Epigenetic regulation and chromatin remodeling in learning and memory
Experimental and Molecular Medicine
2017 .01
-
Methylation and demethylation of DNA and histones in chromatin: the most complicated epigenetic marker
Experimental and Molecular Medicine
2017 .01
-
Visualization of chromatin higher-order structures and dynamics in live cells
BMB Reports
2021 .10
-
Molecular Dynamics Study of Static and Dynamic Structure of Single Polymer Chain Under Spherical Confinement
한국고분자학회 학술대회 연구논문 초록집
2021 .10
-
Advances in the multimodal analysis of the 3D chromatin structure and gene regulation
Experimental and Molecular Medicine
2024 .04
-
Trans-tail regulation-mediated suppression of cryptic transcription
Experimental and Molecular Medicine
2021 .11
-
Hypoxia suffocates histone demethylases to change gene expression: a metabolic control of histone methylation
BMB Reports
2017 .01
-
Modulation of gene expression dynamics by co-transcriptional histone methylations
Experimental and Molecular Medicine
2017 .01
-
Analysis of opposing histone modifications H3K4me3 and H3K27me3 reveals candidate diagnostic biomarkers for TNBC and gene set prediction combination
BMB Reports
2020 .01
-
Advances in higher-order chromatin architecture: the move towards 4D genome
BMB Reports
2021 .01
-
LSD1: more than demethylation of histone lysine residues
Experimental and Molecular Medicine
2020 .12
-
4D nucleome: dynamic three-dimensional genome organization over time
Experimental and Molecular Medicine
2024 .04
-
Histone lysine demethylases in mammalian embryonic development
Experimental and Molecular Medicine
2017 .01
-
HSV-1 ICP27 represses NF-κB activity by regulating Daxx sumoylation
BMB Reports
2017 .01
-
Writing, erasing and reading histone lysine methylations
Experimental and Molecular Medicine
2017 .01
최근 본 자료
댓글(0)
0