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논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2003.1
- 수록면
- 98 - 105 (8page)
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Human 8-oxo-G-DNA glycosylase 1 (hOGG1) is a DNA glycosylase to cleave 8-oxo-7,8-dihydrogua-nine (8-oxo-G), a mutagenic DNA adduct formed by oxidant stresses. Here, we examined hOG1 protein expression and repair activity to nick a DNA strand at the site of 8-oxo-G during difer-entiation of hematopoietic cels using HL-60 cels. Overal expresion of hOGG1 protein was in-creased during granulocytic diferentiation of HL-60 cels induced by DMSO and monocytic difer-entiation by vitamine D3. Greater level of hOG1 protein was expressed in DMSO-treated cels. How-ever, change in the DNA nicking activity was not in paralel with the change in hOG1 protein ex-pression, especialy in PMA-treated cells. In PMA- treated cels, the level of hOG1 protein was lower-ed, even though the DNA nicking activity was elev-ated, in a maner similar to the changes in serum- deprived HL-60 cels. These results indicate that hOGG1 expresion change during diferentiation of hematopoietic stem cels for adaptation to new require aditional factor(s) other than expresed hOG1 protein, especialy in apoptotic cel death.
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