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논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2004.1
- 수록면
- 454 - 460 (7page)
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초록· 키워드
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Hepatitis C Virus (HCV) is associated with a severe liver disease and increased frequency in Overexpresion of HCV core protein is known to transform fibroblast cells. Phospholipase D (PLD) activity is comonly elevated in response to mitogenic signals, and has also ben overex-pressed and hyperactivated in some human cancer cels. The aim of this study was to understand how PLD was regulated in the HCV core protein-transformed NIH3T3 mouse fibro-blast cels. We observed that PLD activity was elevated in the NIH3T3 cels overexpresing HCV core protein over the vector alone-trans-of PLD protein and protein kinase C (PKC) in the HCV core protein-transformed cels was si-milar to the control cells. Phorbol 12-myristate 13-acetate (PMA), which is known to activate PKC, stimulated PLD activity significantly more in the core protein-transformed cels, in com-parison with that of the control cels. PLD activity assay using PKC isozyme-specific inhi-bitor and PKC translocation experiment showed that PKC-δ was mainly involved in the PMA- cells. Moreover, in cells overexpresing HCV core protein, PMA also stimulated p38 kinase more potently than that of the control cels, and an inhibitor of p38 kinase abolished PMA-in-duced PLD activation in cells overexpressing HCV core protein. Taken together, these results sugest that PLD might be implicated in core protein-induced transformation.
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참고문헌 (31)
참고문헌 신청
/ / Phosphatidylcholine-specific phospholipase D activity is elevated in v-Fpstransformedcells : 1195 ~ 03
/ 1990 / Hepatitis C virus infection is associated with thedevelopment of hepatocellular carcinoma : 6547 ~ 9
/ 1997 / Characterization of two alternately spliced forms of phospholipaseD1 Activation of the purified enzymes by phosphatidylinositol4 (zawa y) : 5 3860 ~ 8
/ 1997 / Increased phospholipaseD activity in human breast cancer : 280 ~ 5
/ 1997 / Increases of ARF-dependent PLD activity inregenerating liver cells ban (y zawa y) : 5208 ~ 13
/ 1990 / Hepatitis C virus infection is associated with thedevelopment of hepatocellular carcinoma : 6547 ~ 9
/ 1997 / Characterization of two alternately spliced forms of phospholipaseD1 Activation of the purified enzymes by phosphatidylinositol4 (zawa y) : 5 3860 ~ 8
/ 1997 / Increased phospholipaseD activity in human breast cancer : 280 ~ 5
/ 1997 / Increases of ARF-dependent PLD activity inregenerating liver cells ban (y zawa y) : 5208 ~ 13
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