개인구독
소속 기관이 없으신 경우, 개인 정기구독을 하시면 저렴하게
논문을 무제한 열람 이용할 수 있어요.
지원사업
학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
커뮤니티
연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2008.1
- 수록면
- 514 - 522 (9page)
이용수
초록· 키워드
오류제보하기
Tumor migration/invasion is the main cause of tumor progression and STAT3 is needed to enhance tumor migration/invasion by up-regulating MMP-9. Thus, agents that inhibit STAT3 activation may be used as an anticancer drug. We present herein that 6-methyl- 2-propylimino-6, 7-dihydro-5H-benzo [1, 3]-oxathiol- 4-one (LYR71) , a derivative of trimeric resveratrol, has an anticancer activity through inhibition of STAT3 activation. We found that LYR71 suppressed STAT3 activation and inhibited the expression and activity of MMP-9 in RANTES-stimulated breast cancer cells. In addition, LYR71 reduced RANTES-induced MMP-9 transcripts by blocking STAT3 recruitment, dissociating p300 and deacetylating histone H3 and H4 on the MMP-9 promoter. Furthermore, LYR71 inhibited tumor migration/invasion in RANTES-treated breast cancer cells and consequently blocked tumor progression in tumor-bearing mice. Taken together, the results of this study suggest that LYR71 can be therapeutically useful due to the inhibition effect of STAT3-mediated MMP-9 expression in breast cancer cells.
목차
등록된 정보가 없습니다.
참고문헌 (23)
참고문헌 신청
Azenshtein E / 2002 / The CC chemokine RANTES in breast carcinoma progression: regulation of expression and potential mechanisms of promalignant activity / Cancer Res 62 : 10
Aziz MH / 2005 / Chemoprevention of skin cancer by grape constituent resveratrol: relevance to human disease? / FASEB J 19 : 1193 ~ 5
Birrell MA / 2005 / Resveratrol, an extract of red wine, inhibits lipopolysaccharide induced airway neutrophilia and inflammatory mediators through an NF-kappaB-independent m
Busquets S / 2007 / Resveratrol, a natural diphenol, reduces metastatic growth in an experimental cancer model / Cancer Lett 245 : 144 ~ 8
Chen EI / 2006 / Maspin and tumor metastasis / IUBMB Life 58 : 25 ~ 9
Aziz MH / 2005 / Chemoprevention of skin cancer by grape constituent resveratrol: relevance to human disease? / FASEB J 19 : 1193 ~ 5
Birrell MA / 2005 / Resveratrol, an extract of red wine, inhibits lipopolysaccharide induced airway neutrophilia and inflammatory mediators through an NF-kappaB-independent m
Busquets S / 2007 / Resveratrol, a natural diphenol, reduces metastatic growth in an experimental cancer model / Cancer Lett 245 : 144 ~ 8
Chen EI / 2006 / Maspin and tumor metastasis / IUBMB Life 58 : 25 ~ 9
함께 읽어보면 좋을 논문
논문 유사도에 따라 DBpia 가 추천하는 논문입니다. 함께 보면 좋을 연관 논문을 확인해보세요!
-
Benzoxathiol derivative BOT-4-one suppresses L540 lymphoma cell survival and proliferation via inhibition of JAK3/STAT3 signaling
Experimental and Molecular Medicine
2011 .01
-
Hypoxia activates the cyclin D1 promoter via the Jak2/STAT5b pathway in breast cancer cells
Experimental and Molecular Medicine
2005 .01
-
Hypoxia activates signal transducers and activators of transcription 5 (STAT5) and increases its binding activity to the GAS element in mammary epithelial cells
Experimental and Molecular Medicine
2003 .01
-
Modulation of the caveolin-3 localization to caveolae and STAT3 to mitochondria by catecholamine-induced cardiac hypertrophy in H9c2 cardiomyoblasts
Experimental and Molecular Medicine
2009 .01
-
신장암 세포주에서 actinomycin D에 의한 SOCS3 발현 감소를 통한 STAT3 활성화
생명과학회지
2011 .01
-
Methyl Linderone Suppresses TPA-Stimulated IL-8 and MMP-9 Expression Via the ERK/STAT3 Pathway in MCF-7 Breast Cancer Cells
Journal of Microbiology and Biotechnology
2020 .01
-
STAT6 Gene Polymorphisms in Allergic Rhinitis
Genomics & informatics
2004 .01
-
Suppression of Antimicrobial Defense and Stabilization of STAT3 by IRAK-M Expression in Tumor Cells Promotes Colorectal Carcinogenesis
JOURNAL OF BACTERIOLOGY AND VIROLOGY
2016 .09
-
Anti-inflammatory effects of 8-hydroxydeoxyguanosine in LPS-induced microglia activation: suppression of STAT3-mediated intercellular adhesion molecule-1 expression
Experimental and Molecular Medicine
2006 .01
-
Effect of resveratrol on the metastasis of 4T1 mouse breast cancer cells in vitro and in vivo
Nutrition Research and Practice
2012 .08
-
Effect of resveratrol on the metastasis of 4T1 mouse breast cancer cells in vitro and in vivo
Nutrition Research and Practice
2012 .08
-
Activated Rac1 regulates the degradation of IκBα and the nuclear translocation of STAT3–NFκB complexes in starved cancer cells
Experimental and Molecular Medicine
2016 .01
-
Triptolide inhibits ovarian cancer cell invasion by repression of matrix metalloproteinase 7 and 19 and upregulation of E-cadherin
Experimental and Molecular Medicine
2012 .01
-
A functional comparison between the HER2high/HER3 and the HER2low/HER3 dimers on heregulin-β1-induced MMP-1 and MMP-9 expression in breast cancer cells
Experimental and Molecular Medicine
2012 .01
-
Naringenin이 NF-κB, AP-1 억제를 통한 MMP-9 활성 및 발현 억제 효과
환경생물
2009 .01
-
Regulation of expression of matrix metalloproteinase-9 by JNK in Raw 264.7 cells: presence of inhibitory factor(s) suppressing MMP-9 induction in serum and conditioned media
Experimental and Molecular Medicine
2009 .01
-
Resveratrol에 의한 암 전이 관련 유전자 MMP-9의 발현 조절
JOURNAL OF BACTERIOLOGY AND VIROLOGY
2003 .09
-
Disulfiram에 의한 type Ⅳ collagenase 저해효과
생명과학회지
2006 .10
-
Synthesis of Thienopyrimidine Derivatives as Inhibitors of STAT3 Activation Induced by IL-6
Journal of Microbiology and Biotechnology
2019 .01
이 논문의 저자 정보
최근 본 자료
댓글(0)
0