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학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
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연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2009.1
- 수록면
- 25 - 32 (8page)
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초록· 키워드
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The purpose of this study was to develop a novel polymer
cuff for the local delivery of α-lipoic acid (ALA) to
inhibit neointimal formation in vivo. The polymer cuff
was fabricated by incorporating the ALA into poly-
(D,L-lactide-co-caprolactone) 40:60 (PLC), with or without
methoxy polyethylene glycol (MethoxyPEG). The
release kinetics of ALA and in vitro degradation by hydrolysis
were analyzed by HPLC and field emission
scanning electron microscopy (FE-SEM), respectively.
In vivo evaluation of the effect of the ALA-containing
polymer cuff was carried out using a rat femoral
artery cuff injury model. At 24 h, 48% or 87% of the ALA
was released from PCL cuffs with or without
MethoxyPEG. FE-SEM results indicated that ALA was
blended homogenously in the PLC with MethoxyPEG,
whereas ALA was distributed on the surface of the PLC
cuff without MethoxyPEG. The PLC cuff with MethoxyPEG
showed prolonged and controlled release of ALA in PBS, in contrast to the PLC cuff without
MethoxyPEG. Both ALA-containing polymer cuffs had
a significant effect on the inhibition of neointimal formation
in rat femoral artery. Novel ALA-containing polymer
cuffs made of PLC were found to be biocompatible
and effective in inhibiting neointimal formation in
vivo. Polymer cuffs containing MethoxyPEG allowed
the release of ALA for one additional week, and the rate
of drug release from the PLC could be controlled by
changing the composition of the polymer. These findings
demonstrate that polymer cuffs may be an easy
tool for the evaluation of anti-restenotic agents in animal
models.
목차
등록된 정보가 없습니다.
참고문헌 (20)
참고문헌 신청
Biewenga GP / 1997 / The pharmacology of the antioxidant lipoic acid / Gen Pharmacol 29 : 315 ~ 331
Castoldi G / 2007 / Angiotensin II increases tissuespecific inhibitor of metalloproteinase-2 expression in rat aortic smooth muscle cells in vivo: Evidence of a pressureindep
Eisenberg MJ / 2006 / Review of randomized clinical trials of drug-eluting stents for the prevention of in-stent restenosis / Am J Cardiol 98 : 375 ~ 382
Ferns GA / 1992 / Arterial response to mechanical injury: balloon catheter de-endothelialization / Atherosclerosis 92 : 89 ~ 104
Fuster V / 1995 / The three processes leading to post PTCA restenosis:dependence on the lesion substrate / Thromb Haemost 74 : 552 ~ 559
Castoldi G / 2007 / Angiotensin II increases tissuespecific inhibitor of metalloproteinase-2 expression in rat aortic smooth muscle cells in vivo: Evidence of a pressureindep
Eisenberg MJ / 2006 / Review of randomized clinical trials of drug-eluting stents for the prevention of in-stent restenosis / Am J Cardiol 98 : 375 ~ 382
Ferns GA / 1992 / Arterial response to mechanical injury: balloon catheter de-endothelialization / Atherosclerosis 92 : 89 ~ 104
Fuster V / 1995 / The three processes leading to post PTCA restenosis:dependence on the lesion substrate / Thromb Haemost 74 : 552 ~ 559
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