지원사업
학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
커뮤니티
연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2010.1
- 수록면
- 437 - 445 (9page)
이용수
초록· 키워드
오류제보하기
TNF-α, a proinflammatory cytokine, inhibits osteoblast differentiation under diverse inflammatory conditions;however, the underlying mechanisms in terms of the TNF-α signaling pathway remain unclear. In this study, we examined the role of Msx2 in TNF-α-mediated inhibition of alkaline phosphatase (ALP) expression and the signaling pathways involved. TNF-αdown-regulated ALP expression induced by bone morphogenetic protein 2 (BMP2) in C2C12 and Runx2-/- calvarial cells. Over-expression of Msx2 suppressed BMP2-induced ALP expression. Furthermore, TNF-αinduced Msx2 expression, and the knockdown of Msx2by small interfering RNAs rescued ALP expression,which was inhibited by TNF-α. TNF-α activated the NF-κB and the JNK pathways. Inhibition of NF-κB or JNK activation reduced the inhibitory effect of TNF-αon ALP expression, whereas TNF-α-induced Msx2 expression was only suppressed by the inhibition of the NF-κB pathway. Taken together, these results indicate that Msx2 mediates the inhibitory action of TNF-α on BMP2-regulated osteoblast differentiation and that the TNF-α-activated NF-κB pathway is responsible for Msx2 induction.
목차
등록된 정보가 없습니다.
참고문헌 (24)
참고문헌 신청
Alappat S / 2003 / Msx homeobox gene family and craniofacial development / Cell Res 13 : 429 ~ 442
Boyce BF / 2005 / TNF-alpha and pathologic bone resorption / Keio J Med 54 : 127 ~ 131
Brockman JA / 1995 / Coupling of a signal response domain in I kappa B alpha to multiple pathways for NF-kappa B activation / Mol Cell Biol 15 : 2809 ~ 2818
Chen G / 2002 / TNF-R1 signaling: a beautiful pathway / Science 296 : 1634 ~ 1635
Cheng SL / 2003 / MSX2 promotes osteogenesis and suppresses adipogenic differentiation of multipotent mesenchymal progenitors / J Biol Chem 278 : 45969 ~ 45977
Boyce BF / 2005 / TNF-alpha and pathologic bone resorption / Keio J Med 54 : 127 ~ 131
Brockman JA / 1995 / Coupling of a signal response domain in I kappa B alpha to multiple pathways for NF-kappa B activation / Mol Cell Biol 15 : 2809 ~ 2818
Chen G / 2002 / TNF-R1 signaling: a beautiful pathway / Science 296 : 1634 ~ 1635
Cheng SL / 2003 / MSX2 promotes osteogenesis and suppresses adipogenic differentiation of multipotent mesenchymal progenitors / J Biol Chem 278 : 45969 ~ 45977
함께 읽어보면 좋을 논문
논문 유사도에 따라 DBpia 가 추천하는 논문입니다. 함께 보면 좋을 연관 논문을 확인해보세요!
-
NF-κB is involved in the TNF-α induced inhibition of the differentiation of 3T3-L1 cells by reducing PPARγ expression
Experimental and Molecular Medicine
2003 .01
-
Tumor Necrosis Factor-α Promotes Osteogenesis of Human Bone Marrowderived Mesenchymal Stem Cells through JNK-dependent Pathway
생명과학회지
2006 .12
-
TNF-α upregulates PTEN via NF-κB signaling pathways inhuman leukemic cells
Experimental and Molecular Medicine
2007 .01
-
펩티도글리칸에 의한 단핵세포의 Tumor necrosis factor-α 발현 기전 연구
생명과학회지
2019 .11
-
Homeodomain Protein Msx1에 의한 당단백질 Subunit 유전자의 전사 억제 기작
한국동물학회 학술대회
2003 .01
-
NF-kB is Involved in Platelet-Activating Factor (PAF)-Mediated Tumor Necrosis Factor (TNF)-$\alpha$ Gene Expression
한국동물학회 학술대회
1996 .01
-
Transient exposure to hydrogen peroxide inhibits the ubiquitination of phosphorylated IκBα in TNFα-stimulated HEK293 cells
Experimental and Molecular Medicine
2012 .01
-
Inhibitory effect of (-)-epigallocatechin gallate on titanium particle-induced TNF-α release and in vivo osteolysis
Experimental and Molecular Medicine
2011 .01
-
Antioxidant and TNF-α Inducing Ability of Styela plicata Extracts
생명과학회지
2009 .04
-
Signaling pathway for 2,3,7,8-tetrachlorodibenzop-dioxin-induced TNF-α production in differentiated THP-1human macrophages
Experimental and Molecular Medicine
2007 .01
-
Chemical inhibitors destabilize HuR binding to the AU-rich element of TNF-α mRNA
Experimental and Molecular Medicine
2009 .01
-
MC3T3-E1 세포에서 BMP2에 의한 조골세포의 분화에 일주기 유전자 Per1이 미치는 영향
생명과학회지
2017 .05
-
Induction of steroid sulfatase expression by tumor necrosis factor-α through phosphatidylinositol 3-kinase/Akt signaling pathway in PC-3 human prostate cancer cells
Experimental and Molecular Medicine
2011 .01
-
인간유방암 MDA-MB-231 세포에서 청국장추출물에 의한 TNFα 발현억제
미생물학회지
2016 .09
-
인간유방암 MDA-MB-231세포에서 peptide H에 의한 TNFα 발현 억제
미생물학회지
2015 .09
-
Lack of Association between Tumor Necrosis Factor-α-308 and -238 Promoter Polymorphisms and Chronic Hepatitis B Virus Infection
생명과학회지
2008 .09
이 논문의 저자 정보
최근 본 자료
댓글(0)
0