지원사업
학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
커뮤니티
연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2016.1
- 수록면
- 245 - 246 (2page)
이용수
초록· 키워드
오류제보하기
The level and activity of critical regulatory proteins in cells are tightly controlled by several tiers of post-translational modifications. HIF-1α is maintained at low levels under normoxia conditions by the collaboration between PHD proteins and the VHL-containing E3 ubiquitin ligase complex. We recently identified a new physiologically relevant mechanism that regulates HIF-1α stability in the nucleus in response to cellular oxygen levels. This mechanism is based on the collaboration between the SET7/9 methyltransferase and the LSD1 demethylase. SET7/9 adds a methyl group to HIF-1α, which triggers degradation of the protein by the ubiquitin-proteasome system, whereas LSD1 removes the methyl group, leading to stabilization of HIF-1α under hypoxia conditions. In cells from knock-in mice with a mutation preventing HIF-1α methylation (Hif1αKA/KA), HIF-1α levels were increased in both normoxic and hypoxic conditions. Hif1αKA/KA knock-in mice displayed increased hematological parameters, such as red blood cell count and hemoglobin concentration. They also displayed pathological phenotypes; retinal and tumor-associated angiogenesis as well as tumor growth were increased in Hif1αKA/KA knock-in mice. Certain human cancer cells exhibit mutations that cause defects in HIF-1α methylation. In summary, this newly identified methylation-based regulation of HIF-1α stability constitutes another layer of regulation that is independent of previously identified mechanisms.
목차
등록된 정보가 없습니다.
참고문헌 (0)
참고문헌 신청함께 읽어보면 좋을 논문
논문 유사도에 따라 DBpia 가 추천하는 논문입니다. 함께 보면 좋을 연관 논문을 확인해보세요!
-
Phospholipase D2 promotes degradation of hypoxia-inducible factor-1α independent of lipase activity
Experimental and Molecular Medicine
2015 .01
-
Determination of HIF-1α degradation pathways via modulation of the propionyl mark
BMB Reports
2023 .04
-
Hypoxia-inducible factor-2α mediates senescence-associated intrinsic mechanisms of age-related bone loss
Experimental and Molecular Medicine
2021 .04
-
Hypoxia, oxidative stress, and the interplay of HIFs and NRF2 signaling in cancer
Experimental and Molecular Medicine
2024 .03
-
Hypoxia signaling in human diseases and therapeutic targets
Experimental and Molecular Medicine
2019 .01
-
Homocysteine-targeting compounds as a new treatment strategy for diabetic wounds via inhibition of the histone methyltransferase SET7/9
Experimental and Molecular Medicine
2022 .07
-
Suppression of Akt-HIF-1α signaling axis by diacetyl atractylodiol inhibits hypoxia-induced angiogenesis
BMB Reports
2016 .01
-
Mechanism of the natural product moracin-O derived MO-460 and its targeting protein hnRNPA2B1 on HIF-1α inhibition
Experimental and Molecular Medicine
2019 .01
-
Activation of the osteoblastic HIF-1α pathway partially alleviates the symptoms of STZ-induced type 1 diabetes mellitus via RegIIIγ
Experimental and Molecular Medicine
2024 .07
-
TP53I11 suppresses epithelial-mesenchymal transition and metastasis of breast cancer cells
BMB Reports
2019 .01
-
Histone demethylase KDM4A plays an oncogenic role in nasopharyngeal carcinoma by promoting cell migration and invasion
Experimental and Molecular Medicine
2021 .08
-
Effects of long-term tubular HIF-2α overexpression on progressive renal fibrosis in a chronic kidney disease model
BMB Reports
2023 .03
-
Crosstalk between FLS and chondrocytes is regulated by HIF-2α-mediated cytokines in arthritis
Experimental and Molecular Medicine
2015 .01
-
The pleckstrin homology domain of phospholipase D1 accelerates EGFR endocytosis by increasing the expression of the Rab5 effector, rabaptin-5
Experimental and Molecular Medicine
2015 .01
-
Pre-activation of HIF-1α Using PHD Inhibitor Reduces Cisplatin-induced Nephrotoxicity
한국생물공학회 학술대회
2021 .10
-
Tangeretin Maintains Skin Homeostasis by Inhibiting Cutaneous HIF-1α and NF-κB Crosstalk Induced by Phorbol Ester in Mice Model
한국생물공학회 학술대회
2019 .10
-
Hypoxic repression of CYP7A1 through a HIF-1α- and SHP-independent mechanism
BMB Reports
2016 .01
-
Hypoxia and aging
Experimental and Molecular Medicine
2019 .01
이 논문의 저자 정보
최근 본 자료
댓글(0)
0