지원사업
학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
커뮤니티
연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2016.1
- 수록면
- 218 - 226 (9page)
이용수
초록· 키워드
오류제보하기
Helicobacter pylori primarily colonizes the human stomach. Infection by this bacterium is associated with various gastric diseases, including inflammation, peptic ulcer, and gastric cancer. Although there are antibiotic regimens for the eradication of H. pylori, the resistance of this species against antibiotics has been continuously increasing. The natural compound plumbagin has been reported as an antimicrobial and anticancer molecule. In this study, we analyzed the inhibitory effect of plumbagin on H. pylori strain ATCC 49503 as well as the expression of various molecules associated with H. pylori growth or virulence by immunoblotting and reverse transcription polymerase chain reaction (RT-PCR) analyses. We demonstrated the minimal inhibitory concentration of plumbagin on H. pylori through the agar dilution and broth dilution methods. Furthermore, we investigated the effect of plumbagin treatment on the expression of the RNA polymerase subunits and various virulence factors of H. pylori. Plumbagin treatment decreased the expression of RNA polymerase subunit alpha (rpoA), which is closely associated with bacterial survival. Moreover, the mRNA and protein levels of the major CagA and VacA toxins were decreased in plumbagintreated H. pylori cells. Likewise, the expression levels of urease subunit alpha (ureA) and an adhesin (alpA) were decreased by plumbagin treatment. Collectively, these results suggest that plumbagin may inhibit the growth, colonization, and pathogenesis of H. pylori by the mechanism demonstrated in this study.
목차
등록된 정보가 없습니다.
참고문헌 (35)
참고문헌 신청
Borin BN / 2014 / Helicobacter pylori RNA polymerase alpha-subunit C-terminal domain shows features unique to varepsilon-proteobacteria and binds NikR/DNA complexes / Prot. Sci 23:454~463
Bornschein J / 2014 / Helicobacter pylori and gastric cancer / Dig. Dis 32:249~264
Cover TL / 2005 / Helicobacter pylori VacA, a paradigm for toxin multifunctionality / Nat. Rev. Microbiol 3:320~332
Cover TL / 2009 / Helicobacter pylori in health and disease / Gastroenterology 136:1863~1873
Dailidiene D / 2007 / Urea sensitization caused by separation of Helicobacter pylori RNA polymerase beta and beta' subunits / Helicobacter 12:103~111
Bornschein J / 2014 / Helicobacter pylori and gastric cancer / Dig. Dis 32:249~264
Cover TL / 2005 / Helicobacter pylori VacA, a paradigm for toxin multifunctionality / Nat. Rev. Microbiol 3:320~332
Cover TL / 2009 / Helicobacter pylori in health and disease / Gastroenterology 136:1863~1873
Dailidiene D / 2007 / Urea sensitization caused by separation of Helicobacter pylori RNA polymerase beta and beta' subunits / Helicobacter 12:103~111
함께 읽어보면 좋을 논문
논문 유사도에 따라 DBpia 가 추천하는 논문입니다. 함께 보면 좋을 연관 논문을 확인해보세요!
-
Regulation in the Expression of Virulence Factors of Helicobacter pylori by the Interaction between AGS Cells and H. pylori
JOURNAL OF BACTERIOLOGY AND VIROLOGY
2022 .12
-
A Virulence-factor Associated Component of Variation in Helicobacter pylori
한국미생물학회 학술대회논문집
2019 .04
-
Anti-bacterial effects of enzymatically-isolated sialic acid from glycomacropeptide in a Helicobacter pylori-infected murine model
Nutrition Research and Practice
2017 .02
-
Anti-bacterial effects of enzymatically-isolated sialic acid from glycomacropeptide in a Helicobacter pylori-infected murine model
Nutrition Research and Practice
2017 .02
-
Antimicrobial Characterization of Inula britannica against Helicobacter pylori on Gastric Condition
Journal of Microbiology and Biotechnology
2016 .01
-
Increased Risk of Severe Gastric Symptoms by Virulence Factors vacAs1c , alpA , babA2 , and hop Z in Helicobacter pylori Infection
Journal of Microbiology and Biotechnology
2021 .01
-
Characterization and expression of SabA and BabA genes in Helicobacter pylori under varying pH
미생물학회지
2021 .06
-
오수유 메탄올 추출물이 Helicobacter pylori 병원성 관련유전자 발현에 미치는 영향
대한임상검사과학회지
2019 .01
-
A Novel Mechanism by Which Helicobacter pylori Regulates Expression of CagA
한국미생물학회 학술대회논문집
2017 .04
-
Helicobacter pylori Korean Type Culture Collection (HpKTCC) Collects and Distributes Clinical Isolates of H. pylori
한국미생물학회 학술대회논문집
2015 .04
-
Comparative Transcriptome Analysis of Caryophyllene- Treated Helicobacter pylori
한국미생물·생명공학회지
2021 .09
-
Why Does Helicobacter pylori Have a Pathogenicity Island? The Bacterial Perspective
한국미생물학회 학술대회논문집
2018 .04
-
How H. pylori Changes cagA Gene Number
한국미생물학회 학술대회논문집
2017 .04
-
가자미식해에서 분리한 Lactobacillus spp.의 항헬리코박터 활성 평가
생명과학회지
2023 .03
-
Zerumbone 처리에 따른 Helicobacter pylori의 단백질 비교분석
대한임상검사과학회지
2018 .01
-
헬리코박터 파일로리(Helicobacter pylori) 감염 및 치료법 개요
자원환경지질
2015 .01
-
A Diagnostics of In Vivo Response Against Detecting Helicobacter pylori Infection
한국미생물학회 학술대회논문집
2015 .04
-
Proteome Analysis of Alkylhydroxide Peroxidase-Deficient Isogenic Mutant of Helicobacter pylori 26695
JOURNAL OF BACTERIOLOGY AND VIROLOGY
2019 .12
-
Non-Invasive Colorimetric Magneto Loop-Mediated Isothermal Amplification (CM-LAMP) Method for Helicobacter pylori Detection
Journal of Microbiology and Biotechnology
2021 .01
이 논문의 저자 정보
최근 본 자료
댓글(0)
0