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논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 저널정보
- 한국미생물생명공학회 Journal of Microbiology and Biotechnology Journal of Microbiology and Biotechnology 제18권 제2호
- 발행연도
- 2008.1
- 수록면
- 314 - 321 (8page)
이용수
초록· 키워드
오류제보하기
Acaricidal effects of materials derived from Diospyros kaki roots against Dermatophagoides farinae and D. pteronyssinus were assessed using impregnated fabric disk bioassay and compared with that of the commercial benzyl benzoate.
The observed responses varied according to dosage and mite species. The LD50 values of the chloroform extract of Diospyros kaki roots were 1.66 and 0.96 μg/cm2 against D.
farinae and D. pteronyssinus. The chloroform extract of Diospyros kaki roots was approximately 15.2 more toxic than benzyl benzoate against D. farinae, and 7.6 times more toxic against D. pteronyssinus. Purification of the biologically active constituent from D. kaki roots was done by using silica gel chromatography and high-performance liquid chromatography. The structure of the acaricidal component was analyzed by GC-MS, 1H-NMR, 13C-NMR, 1H-13C COSY-NMR, and DEPT-NMR spectra, and identified as plumbagin. The acaricidal activity of plumbagin and its derivatives (naphthazarin, dichlon, 2,3-dibromo-1,4- naphthoquinone, and 2-bromo-1,4-naphthoquinone) was examined. On the basis of LD50 values, the most toxic compound against D. farinae was naphthazarin (0.011 μg/ cm2) followed by plumbagin (0.019 μg/cm2), 2-bromo-1,4- naphthoquinone (0.079 μg/cm2), dichlon (0.422 μg/cm2), and benzyl benzoate (9.14 μg/cm2). Additionally, the skin color of the dust mites was changed from colorless-transparent to dark brown-black by the treatment of plumbagin. Similar results have been exhibited in its derivatives (naphthazarin, dichlon, and 2-bromo-1,4-naphthoquinone). In contrast, little or no discoloration was observed for benzyl benzoate.
From this point of view, plumbagin and its derivatives can be very useful for the potential control agents, lead compounds, and indicator of house dust mites.
목차
등록된 정보가 없습니다.
참고문헌 (23)
참고문헌 신청
Bae, E. A. / 2000 / Constitutive β- glucosidases hydrolyzing ginsenoside Rb1 and Rb2 from human intestinal bacteria. Biol. Pharm / Bull 23 : 1481 ~ 1485
Bielory, L. / 2004 / Complementary and alternative interventions in asthma, allergy, and immunology. Ann / Allergy Asthma Immunol 93 : S45 ~ S54
CHOI, INGYU / 2006 / Fractions of Chamaecyparis obtusa Display Antiallergic Effect in RBL2H3 Cells / Journal of Microbiology and Biotechnology 16 (11) : 1747 ~ 1752
Choo, M. K. / 2003 / Antiallergic activity of ginseng and its ginsenoside / Planta Med 69 : 518 ~ 522
Chung, H. S. / 2002 / Nitric oxide and tumor necrosis factor-alpha production by Ixeris dentata in mouse peritoneal macrophages / Ethnopharmacol 82 : 217 ~ 222
Bielory, L. / 2004 / Complementary and alternative interventions in asthma, allergy, and immunology. Ann / Allergy Asthma Immunol 93 : S45 ~ S54
CHOI, INGYU / 2006 / Fractions of Chamaecyparis obtusa Display Antiallergic Effect in RBL2H3 Cells / Journal of Microbiology and Biotechnology 16 (11) : 1747 ~ 1752
Choo, M. K. / 2003 / Antiallergic activity of ginseng and its ginsenoside / Planta Med 69 : 518 ~ 522
Chung, H. S. / 2002 / Nitric oxide and tumor necrosis factor-alpha production by Ixeris dentata in mouse peritoneal macrophages / Ethnopharmacol 82 : 217 ~ 222
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