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학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
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논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 저널정보
- 한국미생물생명공학회 Journal of Microbiology and Biotechnology Journal of Microbiology and Biotechnology 제27권 제10호
- 발행연도
- 2017.1
- 수록면
- 1,877 - 1,884 (8page)
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초록· 키워드
오류제보하기
Mesenchymal stem cells (MSCs) have been suggested as a primary candidate for cell therapy applications because they have self-renewal and differentiation capabilities. Although they can be expanded in ex vivo system, clinical application of these cells is still limited because they survive poorly and undergo senescence or apoptosis when transplanted and exposed to environmental factors such as oxidative stress. Thus, reducing oxidative stress is expected to improve the efficacy of MSC therapy. The milk protein lactoferrin is a multifunctional ironbinding glycoprotein that plays various roles, including reduction of oxidative stress. Thus, we explored the effect of lactoferrin on oxidative stress-induced senescence and apoptosis of human MSCs (hMSCs). Measurement of reactive oxygen species (ROS) revealed that lactoferrin inhibited the production of hydrogen peroxide-induced intracellular ROS, suggesting lactoferrin as a good candidate as an antioxidant in hMSCs. Pretreatment of lactoferrin suppressed hydrogen peroxide-induced senescence of hMSCs. In addition, lactoferrin reduced hydrogen peroxide-induced apoptosis via inhibition of caspase-3 and Akt activation. These results demonstrate that lactoferrin can be a promising factor to protect hMSCs from oxidative stress-induced senescence and apoptosis, thus increasing the efficacy of MSC therapy.
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등록된 정보가 없습니다.
참고문헌 (24)
참고문헌 신청
Alekseenko LL / 2014 / Sublethal heat shock induces premature senescence rather than apoptosis in human mesenchymal stem cells / Cell Stress Chaperones 19 : 355 ~ 366
Bang OY / 2005 / Autologous mesenchymal stem cell transplantation in stroke patients / Ann. Neurol 57 : 874 ~ 882
Brandl A / 2011 / Oxidative stress induces senescence in human mesenchymal stem cells / Exp. Cell Res 317 : 1541 ~ 1547
Brunet A / 1999 / Akt promotes cell survival by phosphorylating and inhibiting a Forkhead tran
Burova E / 2013 / Sublethal oxidative stress induces the premature senescence of human mesenchymal stem cells derived from endometrium / Oxid. Med. Cell Longev 2013 : 474931
Bang OY / 2005 / Autologous mesenchymal stem cell transplantation in stroke patients / Ann. Neurol 57 : 874 ~ 882
Brandl A / 2011 / Oxidative stress induces senescence in human mesenchymal stem cells / Exp. Cell Res 317 : 1541 ~ 1547
Brunet A / 1999 / Akt promotes cell survival by phosphorylating and inhibiting a Forkhead tran
Burova E / 2013 / Sublethal oxidative stress induces the premature senescence of human mesenchymal stem cells derived from endometrium / Oxid. Med. Cell Longev 2013 : 474931
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