지원사업
학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
커뮤니티
연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2015.3
- 수록면
- 229 - 235 (7page)
- DOI
- 10.14348/molcells.2015.2253
이용수
초록· 키워드
오류제보하기
Nicotinamide (NAM) has been shown to suppress reactive oxygen species (ROS) production in primary human fibroblasts, thereby extending their replicative lifespan when added to the medium during long-term cultivation. Based on this finding, NAM is hypothesized to affect cellular senescence progression by keeping ROS accumulation low.
In the current study, we asked whether NAM is indeed able to reduce ROS levels and senescence phenotypes in cells undergoing senescence progression and those already in senescence. We employed two different cellular models: MCF-7 cells undergoing senescence progression and human fibroblasts in a state of replicative senescence. In both models, NAM treatment substantially decreased ROS levels. In addition, NAM attenuated the expression of the assessed senescence phenotypes, excluding irreversible growth arrest. N-acetyl cysteine, a potent ROS scavenger, did not have comparable effects in the tested cell types.
These data show that NAM has potent antioxidative as well as anti-senescent effects. Moreover, these findings suggest that NAM can reduce cellular deterioration caused by oxidative damage in postmitotic cells in vivo.
목차
등록된 정보가 없습니다.
참고문헌 (32)
참고문헌 신청
Atamna, H. / 2000 / N-t-butyl hydroxylamine, a hydrolysis product of alpha-phenyl-N-t-butyl nitrone, is more potent in delaying senescence in human lung fibroblasts / J. Biol. Chem 275:6741~6748
Burkart, V. / 1999 / Potent beta-cell protection in vitro by an isoquinolinone-derived PARP inhibitor / Horm. Metab. Res 12:641~644
조소희 / 2011 / Kinetics of the Cell Biological Changes Occurring in the Progression of DNA Damage-Induced Senescence / Molecules and Cells 31(6):539~546
Dai, D. F. / 2014 / Mitochondrial oxidative stress in aging and healthspan / Longev. Healthspan 3:6
Dimri, G. P. / 1995 / A biomarker that identifies senescent human cells in culture and in aging skin in vivo / Proc. Natl. Acad. Sci. USA 92:9363~9367
Burkart, V. / 1999 / Potent beta-cell protection in vitro by an isoquinolinone-derived PARP inhibitor / Horm. Metab. Res 12:641~644
조소희 / 2011 / Kinetics of the Cell Biological Changes Occurring in the Progression of DNA Damage-Induced Senescence / Molecules and Cells 31(6):539~546
Dai, D. F. / 2014 / Mitochondrial oxidative stress in aging and healthspan / Longev. Healthspan 3:6
Dimri, G. P. / 1995 / A biomarker that identifies senescent human cells in culture and in aging skin in vivo / Proc. Natl. Acad. Sci. USA 92:9363~9367
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