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논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2021.1
- 수록면
- 138 - 147 (10page)
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The overproduction of reactive nitrogen species (RNS) and reactive oxygen species (ROS) causes oxidative damage to neuronal cells, leading to the progression of neurodegenerative diseases. In this study, we determined the nitric oxide radical (NO), hydroxyl radical (·OH), and superoxide anion radical (O2 ?) scavenging activities of apigenin. Our results showed that apigenin exhibited remarkable, concentration-dependent ·OH, O2 ?, and NO radical scavenging activities. Particularly, apigenin indicated the strongest ·OH radical scavenging activity with 93.38% in the concentration of 100 μM. Furthermore, we also investigated the protective effects of apigenin against hydrogen peroxide (H2O2)-induced oxidative stress in SH-SY5Y cells. The H2O2 treatment resulted in a significant decrease in cell viability, as well as an increase in lactate dehydrogenase (LDH) release and ROS production compared with the H2O2-nontreated SH-SY5Y cells. However, the cell viability significantly increased in the apigenin-treated group, as well as inhibited ROS generation and LDH release compared with the H2O2-induced control group. To elucidate the protective mechanisms of apigenin against oxidative stress in SH-SY5Y, we analyzed the apoptosis-related protein expression. The apigenin treatment resulted in the downregulated expression of apoptosis-related protein markers, such as cytochrome C, cleaved caspase-3, poly (ADP)-ribose polymerase (PARP), and B-cell lymphoma 2-associated X (Bax), as well as the upregulated expression of anti-apoptosis markers such as B-cell lymphoma 2 (Bcl-2). In this study, we report that apigenin exhibits a neuroprotective effect against oxidative stress in SH-SY5Y cells. These results suggest that apigenin may be considered as a potential agent for neurodegenerative disease prevention.
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참고문헌 (62)
참고문헌 신청
Davalli P / 2016 / ROS, cell senescence, and novel molecular mechanisms in aging and agerelated diseases / Oxid. Med. Cell. Longev 2016:3565127
Del Rio LA / 2015 / ROS and RNS in plant physiology : an overview / J. Exp. Bot 66:2827~2837
Phaniendra A / 2015 / Free radicals : properties, sources, targets, and their implication in various diseases / Indian J. Clin. Biochem 30:11~26
Islam MT / 2017 / Oxidative stress and mitochondrial dysfunctionlinked neurodegenerative disorders / Neurol. Res 39:73~82
Bhat AH / 2015 / Oxidative stress, mitochondrial dysfunction and neurodegenerative diseases; a mechanistic insight / Biomed. Pharmacother 74:101~110
Del Rio LA / 2015 / ROS and RNS in plant physiology : an overview / J. Exp. Bot 66:2827~2837
Phaniendra A / 2015 / Free radicals : properties, sources, targets, and their implication in various diseases / Indian J. Clin. Biochem 30:11~26
Islam MT / 2017 / Oxidative stress and mitochondrial dysfunctionlinked neurodegenerative disorders / Neurol. Res 39:73~82
Bhat AH / 2015 / Oxidative stress, mitochondrial dysfunction and neurodegenerative diseases; a mechanistic insight / Biomed. Pharmacother 74:101~110
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