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논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 저널정보
- 한국미생물생명공학회 Journal of Microbiology and Biotechnology Journal of Microbiology and Biotechnology 제28권 제10호
- 발행연도
- 2018.1
- 수록면
- 1,589 - 1,603 (15page)
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Twenty analogs of [Orn6,D-Ala9]α-factor were synthesized and assayed for their biological activities: seven analogs of [Orn6,X9]α-factor, seven analogs of [X6,D-Ala9]α-factor, five analogs of [X5,X6,D-Ala9]α-factor, and native α-factor (X = amino acids). Their biological activities (halo, gene induction, and affinity) were measured using S. cerevisiae Y7925 and LM102 and compared with those of native α-factor (100%). G protein-coupled receptor was expressed in strain LM102 containing pESC-LEU-STE2 vector. [Dap6,D-Ala9]α-factor with weak halo activity (10%) showed the highest receptor affinity (> 230%) and the highest gene induction activity (167%). [Arg6,D-Ala9]α-factor showed the highest halo activity (2,000%). The number of active binding sites per cell (about 20,000 for strain LM102) was determined using a newlydesigned fluorescence-based detector, [Arg6,D-Ala9]α-factor-Edan, with high sensitivity (12,500-fold higher than the absorption-based detector [Orn6]α-factor-[Cys]3).
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참고문헌 (4)
참고문헌 신청
Hee Jun Ahn / 2014 / Highly Active Analogs of α-Factor and Their Activities Against Saccharomyces cerevisiae / Bulletin of the Korean Chemical Society 35(5):1365~1374
안희준 / 2015 / Spectrophotometric Determination of Affinities of α-Factors for Their G Protein-Coupled Receptors in Saccharomyces cerevisiae / Bulletin of the Korean Chemical Society 36(7):1885~1896
홍남주 / 2010 / Structure-Activity Relationships of 13- and 14-Membered Cyclic Partial Retro-Inverso Pentapeptides Related to Enkephalin / Bulletin of the Korean Chemical Society 31(4):874~880
Dong Hee Kim / 2012 / Activity Profiles of Linear, Cyclic Monomer and Cyclic Dimer of Enkephalin / Bulletin of the Korean Chemical Society 33(1):261~269
안희준 / 2015 / Spectrophotometric Determination of Affinities of α-Factors for Their G Protein-Coupled Receptors in Saccharomyces cerevisiae / Bulletin of the Korean Chemical Society 36(7):1885~1896
홍남주 / 2010 / Structure-Activity Relationships of 13- and 14-Membered Cyclic Partial Retro-Inverso Pentapeptides Related to Enkephalin / Bulletin of the Korean Chemical Society 31(4):874~880
Dong Hee Kim / 2012 / Activity Profiles of Linear, Cyclic Monomer and Cyclic Dimer of Enkephalin / Bulletin of the Korean Chemical Society 33(1):261~269
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