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논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2018.1
- 수록면
- 2 - 9 (8page)
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Olfactory receptors (ORs) in mammals are generally considered to function as chemosensors in the olfactory organs of animals. They are membrane proteins that traverse the cytoplasmic membrane seven times and work generally by coupling to heterotrimeric G protein. The OR is a G protein-coupled receptor that binds the guanine nucleotide-binding $G{\alpha}_{olf}$ subunit and the $G{\beta}{\gamma}$ dimer to recognize a wide spectrum of organic compounds in accordance with its cognate ligand. Mammalian ORs were originally identified from the olfactory epithelium of rat. However, it has been recently reported that the expression of ORs is not limited to the olfactory organ. In recent decades, they have been found to be expressed in diverse organs or tissues and even tumors in mammals. In this review, the expression and expected function of olfactory receptors that exist throughout an organism's system are discussed.
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참고문헌 (78)
참고문헌 신청
Vassilatis DK / 2003 / The G protein-coupled receptor repertoires of human and mouse / Proc Natl Acad Sci U S A 100:4903~4908
Fredriksson R / 2003 / The G-protein-coupled receptors in the human genome form five main families: phylogenetic analysis, paralogon groups, and fingerprints / Mol Pharmacol 63:1256~1272
Downes GB / 1999 / The G protein subunit gene families / Genomics 62:544~552
Syrovatkina V / 2016 / Regulation, signaling, and physiological functions of G-proteins / J Mol Biol 428:3850~3868
Buck L / 1991 / A novel multigene family may encode odorant receptors: a molecular basis for odor recognition / Cell 65:175~187
Fredriksson R / 2003 / The G-protein-coupled receptors in the human genome form five main families: phylogenetic analysis, paralogon groups, and fingerprints / Mol Pharmacol 63:1256~1272
Downes GB / 1999 / The G protein subunit gene families / Genomics 62:544~552
Syrovatkina V / 2016 / Regulation, signaling, and physiological functions of G-proteins / J Mol Biol 428:3850~3868
Buck L / 1991 / A novel multigene family may encode odorant receptors: a molecular basis for odor recognition / Cell 65:175~187
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