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논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 저널정보
- 한국미생물생명공학회 Journal of Microbiology and Biotechnology Journal of Microbiology and Biotechnology 제25권 제7호
- 발행연도
- 2015.1
- 수록면
- 1,146 - 1,153 (8page)
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This study was conducted to assess the relationship between occurrence of gastric cancer and peptic ulcer, and the presence of H. pylori cagA gene and anti-CagA IgG, and to estimate the value of these antibodies in detecting infection by cagA gene-positive H. pylori strains in Saudi patients. The study included 180 patients who were subjected to upper gastrointestinal endoscopy in Taif province and Western region of Saudi Arabia (60 gastric cancer, 60 peptic ulcer, and 60 with non-ulcer dyspepsia). Gastric biopsy specimens were obtained and tested for H. pylori infection by rapid urease test and culture. PCR was performed on the isolated strains and biopsy specimens for detection of the cagA gene. Blood samples were collected and tested for CagA IgG by ELISA. H. pylori infection was detected among 72.8% of patients. The cagA gene and anti-CagA IgG were found in 63.4% and 61.8% of H. pylori-infected patients, respectively. They were significantly (p < 0.01) higher in patients with gastric cancer and peptic ulcer compared with those with non-ulcer dyspepsia. Detection of the CagA IgG was 91.6% sensitive, 89.6% specific, and 90.8% accurate compared with detection of the cagA gene. Its positive and negative predictive values were 93.8% and 86%, respectively. The study showed a significant association between the presence of the cagA gene and gastric cancer and peptic ulcer disease, and between anti-CagA IgG and the cagA gene in Saudi patients. However, a further larger study is required to confirm this finding.
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참고문헌 (22)
참고문헌 신청
Abo-Shadi MA / 2013 / Clinical, endoscopic, pathological and serological findings of Helicobacter pylori infection in Saudi patients with upper gastrointestinal diseases / Br
Amer FA / 2013 / Helicobacter pylori genotypes among patients in a university hospital in Egypt: identifying the determinant of disease severity / J. Microbiol. Infect. Dis 3
Argent RH / 2008 / Functional association between the Helicobacter pylori virulence factors VacA and CagA / J. Med. Microbiol 57 : 145 ~ 150
Atherton J. / 2006 / The pathogenesis of H pylori?induced gastro-duodenal diseases / Annu. Rev. Pathol 1 : 63 ~ 96
Ayoola AE / 2004 / Prevalence of Helicobacter pylori infection among patients with dyspepsia in South-Western Saudi Arabia / Saudi Med. J 25 : 1433 ~ 1438
Amer FA / 2013 / Helicobacter pylori genotypes among patients in a university hospital in Egypt: identifying the determinant of disease severity / J. Microbiol. Infect. Dis 3
Argent RH / 2008 / Functional association between the Helicobacter pylori virulence factors VacA and CagA / J. Med. Microbiol 57 : 145 ~ 150
Atherton J. / 2006 / The pathogenesis of H pylori?induced gastro-duodenal diseases / Annu. Rev. Pathol 1 : 63 ~ 96
Ayoola AE / 2004 / Prevalence of Helicobacter pylori infection among patients with dyspepsia in South-Western Saudi Arabia / Saudi Med. J 25 : 1433 ~ 1438
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