지원사업
학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
커뮤니티
연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 저널정보
- 한국미생물생명공학회 Journal of Microbiology and Biotechnology Journal of Microbiology and Biotechnology 제27권 제1호
- 발행연도
- 2017.1
- 수록면
- 49 - 56 (8page)
이용수
이 논문의 연구 히스토리 (2)
2017
Tilianin inhibits MUC5AC expression mediated via down-regulation of EGFR-MEK-ERK-Sp1 signaling pathway in NCI-H292 human airway cells
송원용
생명공학과
2017.01
학위논문
Tilianin Inhibits MUC5AC Expression Mediated Via Down-Regulation of EGFR-MEK-ERK-Sp1 Signaling Pathway in NCI-H292 Human Airway Cells
송원용
,
송용석
,
류형원
외 3명
Journal of Microbiology and Biotechnology
2017.01
학술저널
- 이 논문의 후속연구가 궁금하신가요?
- 연관 학술논문 또는 학술발표를 통해 보다 발전된 연구결과를 확인하실 수 있습니다.
- 이 논문의 연구 히스토리 확인하기
초록· 키워드
오류제보하기
In the human airway, mucus exists to protect the respiratory system as a primary barrier of the innate immune system. However, hyperexpressed mucus limits airflow, resulting in a decrease of lung function. Among more than 20 mucin family members, MUC5AC and MUC5B are major glycoproteins in human airway mucus. The epidermal growth factor receptor (EGFR) signaling pathway is one of the mechanisms of these mucins expression and specificity protein-1 (Sp1) transcription factor is the downstream signal of this pathway, playing pivotal roles in mucin expression. Even though there are some drugs for treating mucus hypersecretion, no drug has proven effects on humans. We found that the flavonoid tilianin regulated MUC5AC expression and also inhibited Sp1 phosphorylation. In this study, we investigated how tilianin would modulate EGFR signaling and regulate mucin production. In conclusion, tilianin inhibited MUC5AC expression mediated via modulating the EGFRMEK- ERK-Sp1 signaling pathway in NCI-H292 human airway epithelial cells. This study may provide the basis for the novel treatment of mucus hypersecretion.
목차
등록된 정보가 없습니다.
참고문헌 (24)
참고문헌 신청
Berger JT / 1999 / Respiratory carcinoma cell lines. MUC genes and glycoconjugates / Am. J. Respir. Cell Mol. Biol 20 : 500 ~ 510
Brito AF / 2015 / Quercetin in cancer treatment, alone or in combination with conventional therapeutics? / Curr. Med. Chem 22 : 3025 ~ 3039
Burgel PR / 2008 / Epidermal growth factor receptor-mediated innate immune responses and their roles in airway diseases / Eur. Respir. J 32 : 1068 ~ 1081
Casalino-Matsuda SM / 2006 / Epidermal growth factor receptor activation by epidermal growth factor mediates oxidant-induced goblet cell metaplasia in human airway epithelium
Desta KT / 2016 / The polyphenolic profiles and antioxidant effects of Agastache rugosa Kuntze (Banga) flower, leaf, stem and root / Biomed. Chromatogr 30 : 225 ~ 231
Brito AF / 2015 / Quercetin in cancer treatment, alone or in combination with conventional therapeutics? / Curr. Med. Chem 22 : 3025 ~ 3039
Burgel PR / 2008 / Epidermal growth factor receptor-mediated innate immune responses and their roles in airway diseases / Eur. Respir. J 32 : 1068 ~ 1081
Casalino-Matsuda SM / 2006 / Epidermal growth factor receptor activation by epidermal growth factor mediates oxidant-induced goblet cell metaplasia in human airway epithelium
Desta KT / 2016 / The polyphenolic profiles and antioxidant effects of Agastache rugosa Kuntze (Banga) flower, leaf, stem and root / Biomed. Chromatogr 30 : 225 ~ 231
함께 읽어보면 좋을 논문
논문 유사도에 따라 DBpia 가 추천하는 논문입니다. 함께 보면 좋을 연관 논문을 확인해보세요!
-
Butyrate modulates bacterial adherence on LS174T human colorectal cells by stimulating mucin secretion and MAPK signaling pathway
Nutrition Research and Practice
2015 .08
-
Butyrate modulates bacterial adherence on LS174T human colorectal cells by stimulating mucin secretion and MAPK signaling pathway
Nutrition Research and Practice
2015 .08
-
Transforming Growth Factor β Inhibits MUC5AC Expression by Smad3/HDAC2 Complex Formation and NF-κB Deacetylation at K310 in NCI-H292 Cells
Molecules and Cells
2021 .01
-
15-Hydroxyeicosatetraenoic Acid Inhibits Phorbol-12-Myristate-13- Acetate-Induced MUC5AC Expression in NCI-H292 Respiratory Epithelial Cells
Journal of Microbiology and Biotechnology
2015 .01
-
Novel glutathione-containing dry-yeast extracts inhibit eosinophilia and mucus overproduction in a murine model of asthma
Nutrition Research and Practice
2017 .12
-
Novel glutathione-containing dry-yeast extracts inhibit eosinophilia and mucus overproduction in a murine model of asthma
Nutrition Research and Practice
2017 .12
-
Mucin2 is Required for Probiotic Agents-Mediated Blocking Effects on Meningitic E. coli-Induced Pathogenicities
Journal of Microbiology and Biotechnology
2015 .01
-
Identification of Essential Genes of Pseudomonas aeruginosa for It Is Growth in Airway Mucus
한국미생물학회 학술대회논문집
2016 .04
-
Rare minisatellite alleles of MUC2-MS8 influence susceptibility to rectal carcinoma
Genes & Genomics
2021 .12
-
New Insights into the Protein Turnover Regulation in Ethylene Biosynthesis
Molecules and Cells
2015 .07
-
δ-Catenin Increases the Stability of EGFR by Decreasing c-Cbl Interaction and Enhances EGFR/Erk1/2 Signaling in Prostate Cancer
Molecules and Cells
2018 .03
-
구면굴절력 가입에 따른 경사AC/A비와 반응AC/A비의 비교 연구
대한시과학회지
2015 .01
-
Cross-talk between Mucin Degrading Bacteria and Intestinal Stem Cells Controls Epithelial Development
한국미생물학회 학술대회논문집
2021 .08
-
Reduced EGFR Level in eIF2α Phosphorylation-Deficient Hepatocytes Is Responsible for Susceptibility to Oxidative Stress
Molecules and Cells
2020 .01
-
Effects of Mucin Depletion in Akkermansia muciniphila and a Metabolic Disease Animal Model
한국미생물학회 학술대회논문집
2020 .10
-
H9 Induces Apoptosis via the Intrinsic Pathway in Non-Small-Cell Lung Cancer A549 Cells
Journal of Microbiology and Biotechnology
2015 .01
-
Deoxypodophyllotoxin Inhibits Cell Growth and Induces Apoptosis by Blocking EGFR and MET in Gefitinib-Resistant Non-Small Cell Lung Cancer
Journal of Microbiology and Biotechnology
2021 .01
-
Transcriptomic profiling of the cold stress and recovery responsiveness of two contrasting Guizhou HE rice genotypes
Genes & Genomics
2023 .04
-
Comparative Genomic Analysis of Human Intestinal Mucin-degrading Bacterium Akkermansia muciniphila Isolated from Korean Feces
한국미생물학회 학술대회논문집
2019 .04
-
Comparative Genomic Analysis of Human Intestinal Mucin-degrading Bacterium Akkermansia muciniphila Isolated from Korean Feces
한국미생물학회 학술대회논문집
2019 .04
이 논문의 저자 정보
최근 본 자료
댓글(0)
0