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학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
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논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 저널정보
- 한국미생물생명공학회 Journal of Microbiology and Biotechnology Journal of Microbiology and Biotechnology 제28권 제6호
- 발행연도
- 2018.1
- 수록면
- 883 - 892 (10page)
이용수
초록· 키워드
오류제보하기
Probiotics, including Enterococcus faecium, confer a health benefit on the host. An Enterococcus strain was isolated from healthy chicken cecum, identified as E. faecium by 16S rDNA gene sequence analysis, and designated as E. faecium L11. To evaluate the potential of E. faecium L11 as a probiotic, the gastrointestinal tolerance, immunomodulatory activity, and lifespan extension properties of the strain were assayed. E. faecium L11 showed >66% and >62% survival in artificial gastric juice (0.3% pepsin, pH 2.5) and simulated small intestinal juice (0.5% bile salt and 0.1% pancreatin), respectively. Heat-killed E. faecium L11 significantly (p < 0.05) increased immune cell proliferation compared with controls, and stimulated the production of cytokines (IL-6 and TNF-α) by activated macrophages obtained from ICR mice. In addition, E. faecium L11 showed a protective effect against Salmonella Typhimurium infection in Caenorhabditis elegans. In addition, feeding E. faecium L11 significantly (p < 0.05) extended the lifespan of C. elegans compared with the control. Furthermore, genes related to aging and host defense were upregulated in E. faecium L11-fed worms. In conclusion, E. faecium L11, which prolongs the lifespan of C. elegans, may be a potent probiotic supplement for livestock.
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등록된 정보가 없습니다.
참고문헌 (50)
참고문헌 신청
Wang Z / 2014 / Dietary Enterococcus faecium NCIMB 10415 and zinc oxide stimulate immune reactions to trivalent influenza vaccination in pigs but do not affect virological response upon challenge infection / PLoS One 9:e87007
Tsai Y-T / 2012 / The immunomodulatory effects of lactic acid bacteria for improving immune functions and benefits / Appl. Microbiol. Biotechnol. 96:853~862
Signorini M / 2012 / Impact of probiotic administration on the health and fecal microbiota of young calves: a meta-analysis of randomized controlled trials of lactic acid bacteria / Res. Vet. Sci. 93:250~258
Brestoff JR / 2013 / Commensal bacteria at the interface of host metabolism and the immune system / Nat. Immunol. 14:676~684
Hooper LV / 2012 / Interactions between the microbiota and the immune system / Science 336:1268~1273
Tsai Y-T / 2012 / The immunomodulatory effects of lactic acid bacteria for improving immune functions and benefits / Appl. Microbiol. Biotechnol. 96:853~862
Signorini M / 2012 / Impact of probiotic administration on the health and fecal microbiota of young calves: a meta-analysis of randomized controlled trials of lactic acid bacteria / Res. Vet. Sci. 93:250~258
Brestoff JR / 2013 / Commensal bacteria at the interface of host metabolism and the immune system / Nat. Immunol. 14:676~684
Hooper LV / 2012 / Interactions between the microbiota and the immune system / Science 336:1268~1273
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