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학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
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논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 저널정보
- 한국미생물생명공학회 Journal of Microbiology and Biotechnology Journal of Microbiology and Biotechnology 제27권 제6호
- 발행연도
- 2017.6
- 수록면
- 1,071 - 1,077 (7page)
- DOI
- 10.4014/jmb.1611.11020
이용수
초록· 키워드
오류제보하기
A rise in the occurrence of allergic diseases is attributed to the dysregulated balance of type 1/type 2 immunity, where type 2 T-helper (Th2) cells predominate over type 1 T-helper (Th1) cells, leading to an abnormally increased production of IgE in response to unharmful antigens. Kimchi, a traditional Korean fermented food, is a rich source of beneficial lactic acid bacteria. In this study, we investigated the ability of Enterococcus faecium FC-K derived from kimchi to induce type I immunity in the presence of Th2 polarizing conditions in vitro and in vivo. Stimulation of mouse peritoneal macrophages with E. faecium FC-K induced the production of tumor necrosis factor alpha, interleukin (IL)-6, and IL-12. Under the in vitro Th2 conditions in which splenic T cells were activated in the presence of IL-4, E. faecium FC-K enhanced the ability of T cells to produce interferon (IFN)-γ. Using the ovalbumin (OVA)-induced allergy model, male BALB/c mice receiving E. faecium FC-K reduced the serum level of total IgE, but not that of OVA-specific IgE. Furthermore, the population of activated splenic B cells during OVA immunization was decreased in E. faecium FC-K-treated mice, accounting for a reduction of total IgE in the serum. Restimulating splenocytes from OVA-immunized mice with OVA ex vivo resulted in an increased production of IFN-γ, with no effect on IL-4, in E. faecium FC-Ktreated mice. These observations provide the evidence that E. faecium FC-K can be a beneficial probiotic strain that can modulate the Th2-mediated pathologic response.
목차
등록된 정보가 없습니다.
참고문헌 (25)
참고문헌 신청
Okada H / 2010 / The ‘hygiene hypothesis’ for autoimmune and allergic diseases: an update / Clin. Exp. Immunol 160:1~9
Strachan DP. / 1989 / Hay fever, hygiene, and household size / Brit. Med. J 299:1259~1260
Fahy JV. / 2015 / Type 2 inflammation in asthma - present in most, absent in many / Nat. Rev. Immunol 15:57~65
Kaiko GE / 2008 / Immunological decision-making: how does the immune system decide to mount a helper T-cell response? / Immunology 123:326~338
Kay AB. / 2001 / Allergy and allergic diseases. First of two parts / N. Engl. J . Med 344:30~37
Strachan DP. / 1989 / Hay fever, hygiene, and household size / Brit. Med. J 299:1259~1260
Fahy JV. / 2015 / Type 2 inflammation in asthma - present in most, absent in many / Nat. Rev. Immunol 15:57~65
Kaiko GE / 2008 / Immunological decision-making: how does the immune system decide to mount a helper T-cell response? / Immunology 123:326~338
Kay AB. / 2001 / Allergy and allergic diseases. First of two parts / N. Engl. J . Med 344:30~37
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