지원사업
학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
커뮤니티
연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2018.1
- 수록면
- 453 - 460 (8page)
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초록· 키워드
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ObjectiveIn 2007, the American College of Obstetricians and Gynecologists (ACOG) recommended that all pregnant womenbe offered screening or diagnostic tests for chromosomal abnormalities regardless of their age. Noninvasive prenataltesting (NIPT) for common chromosomal aneuploidies was introduced as a screening test in case of high-riskpregnancies. We assessed the rates of prenatal tests in women aged 35 years and older. MethodsA retrospective study was conducted to compare the rates of amniocentesis, chorionic villus sampling (CVS), serumscreening, and NIPT from January 2005 through March 2017 in women aged 35 years and older. We divided the initial12 months after NIPT introduction into 4-month intervals, beginning in April 2016 through March 2017. ResultsThe rates of amniocentesis were 56% before the ACOG statement, 38% between the ACOG statement and NIPTintroduction, and 10% after NIPT introduction (P=0.001). The rates of CVS during the same periods were 0.5%, 2.1%,and 4.3% (P=0.016), respectively. The rates of serum screening were 44.2%, 61.3%, and 55.1% (P=0.049), respectively. During the 3 quarters after NIPT introduction, the rates of amniocentesis were 16.2%, 12.3%, and 7.3% (P=0.002),respectively; the rates of serum screening were 62%, 54%, and 46% (P=0.03), respectively; and the rates of NIPTwere 19.9%, 30.3%, and 39.5% (P=0.007), respectively. The rates of CVS over the same periods were not significantlydifferent. ConclusionThe ACOG statement and NIPT introduction significantly decreased the rate of amniocentesis in women of advancedmaternal age. NIPT also reduced the rate of serum screening.
목차
등록된 정보가 없습니다.
참고문헌 (15)
참고문헌 신청
Statistics Korea / Planned report, change in birth in Seoul for the past 10 years
Shin Ok Jeong / 2015 / Observed frequency of fetal trisomy between 16 and 24 gestational weeks in pregnant women older than 34 years at delivery / 대한의학유전학회지 12(2):92~95
김영주 / 2013 / Maternal age-specific rates of fetal chromosomal abnormalities in Korean pregnant women of advanced maternal age / Obstetrics & Gynecology Science 56(03):160~166
ACOG Committee on Practice Bulletins / 2007 / ACOG Practice Bulletin No. 77: screening for fetal chromosomal abnormalities / Obstet Gynecol 109:217~227
Driscoll DA / 2009 / Screening for Down syndrome: changing practice of obstetricians / Am J Obstet Gynecol 200:459.e1~459.e9
Shin Ok Jeong / 2015 / Observed frequency of fetal trisomy between 16 and 24 gestational weeks in pregnant women older than 34 years at delivery / 대한의학유전학회지 12(2):92~95
김영주 / 2013 / Maternal age-specific rates of fetal chromosomal abnormalities in Korean pregnant women of advanced maternal age / Obstetrics & Gynecology Science 56(03):160~166
ACOG Committee on Practice Bulletins / 2007 / ACOG Practice Bulletin No. 77: screening for fetal chromosomal abnormalities / Obstet Gynecol 109:217~227
Driscoll DA / 2009 / Screening for Down syndrome: changing practice of obstetricians / Am J Obstet Gynecol 200:459.e1~459.e9
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