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학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
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연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2008.1
- 수록면
- 145 - 146 (2page)
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초록· 키워드
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Alpha-synuclein is a widespread neuronal presynaptic protein found predominantly in the central nervous system, and it is an element of the neuropathological features of several neurodegenerative disorders including the dementia with Lewy bodies and the Parkinson’s disease. At the extra-neural tissue, the normal distribution and functions of α-synuclein remain especially elusive. Though there was one report that described the absence of α-synuclein in human cornea using the Western blots, we had access to data from immunohistochemical staining with fluorescence indicating high immunoreactivity of α-synuclein in human corneal epithelium and endothelium. Our results are consistent with the expression of α-synuclein in the normal human cornea. The presence of α-synuclein in normal human cornea suggests that this molecule is widely distributed and functions in mammalian extra-neural tissue.
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등록된 정보가 없습니다.
참고문헌 (10)
참고문헌 신청
Cooper AA / 2006 / Alpha?synuclein blocks ER?Golgi traffic and Rab1 rescues neuron loss in Parkinson's models / Science 313 : 324 ~ 8
Hashimoto M / 2002 / alpha?Synuclein protects against oxidative stress via inactivation of the c?Jun N?terminal kinase stress?signaling pathway in neuronal cells / J Biol Che
Jakes R / 1994 / Identification of two distinct synucleins from human brain / FEBS Lett 345 : 27 ~ 32
Lee HG / 2006 / Emerging evidence for the neuroprotective role of alpha?synuclein / Exp Neurol 200 : 1 ~ 7
Manning?Bog AB / 2003 / Alpha?synuclein overexpression protects against paraquat?induced neurodegeneration / J Neurosci 23 : 3095 ~ 9
Hashimoto M / 2002 / alpha?Synuclein protects against oxidative stress via inactivation of the c?Jun N?terminal kinase stress?signaling pathway in neuronal cells / J Biol Che
Jakes R / 1994 / Identification of two distinct synucleins from human brain / FEBS Lett 345 : 27 ~ 32
Lee HG / 2006 / Emerging evidence for the neuroprotective role of alpha?synuclein / Exp Neurol 200 : 1 ~ 7
Manning?Bog AB / 2003 / Alpha?synuclein overexpression protects against paraquat?induced neurodegeneration / J Neurosci 23 : 3095 ~ 9
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