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학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
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연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2005.1
- 수록면
- 117 - 122 (6page)
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초록· 키워드
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Background: Epidemiologic studies show that increases in diesel exhaust particles (DEP) can aggravate acute asthma. However, there were a few asthma models in mice exposed to DEP. Nitric oxide (NO) may contributeto airway inflammation and hyperresponsiveness (AHR).
Objective: We have determined the effects of DEP on AHR and inflammation using a mouse model. We have also investigated the effects of DEP on the production of NO in vivo and in vitro.
Method: The mice were intra-nasally sensitized with 0.6 mg/mL of DEP for 5 days and were challenged with 6 mg/m3 of DEP by inhalation route for 3 days. The mice were subjected to whole-body plethysmography and killed for performance of bronchoalveolar lavage and histology. Murine macrophage cell line, Raw 264.7 cellswere exposed to 50μg/mL of DEP and nitrate levels in the culture super-natants were measured with the Griess reagent. Expression of NO synthase was detected by RT-PCR.
Result: DEP induced a significant increase in methacholine- induced AHR. The levels of IL-4 and eotaxin increased in the BAL fluid in mice exposed to DEP. DEP stimulated nitrite production in the BAL fluid. Nitrite increased in Raw 264.7 cells exposed to DEP. DEP stimulated the expression of iNOS in lung tissue in mice exposed to DEP. Alveolar macrophage was expressed iNOS mRNA 24 h and 48 h after stimulation with DEP in vitro with peak time in 48 h post- stimulation.
Conclusion: It is suggested that DEP may induce AHR and produce NO, and that NO may be an important role in airway inflammation by DEP.
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참고문헌 (30)
참고문헌 신청
/ / Bioassy-directed chemical anslysis in environmental reseach
/ 1949-61 / Nitro containing L-arginine analogs interfere with assays for nitrate andnitite
/ AmJRespirCellMolBiol2000 / Synergisticof diesel organic extracts and allergen Der p 1 on the release of chemokines byperipheral blood mononuclear cells from allergic subje
/ AmJRespirCritCareMed1996 / Alveolar destruction in guinea pigs chronically exposed todiesel engine exhaust- A light microscopic and electron microscopic morphometry study
/ AmJRespirCritCareMed1997 / Diesel exhaustparticles enhance antigen-induced airway inflammation and local cytokine expression inmice taka (h) : 36 ~ 42
/ 1949-61 / Nitro containing L-arginine analogs interfere with assays for nitrate andnitite
/ AmJRespirCellMolBiol2000 / Synergisticof diesel organic extracts and allergen Der p 1 on the release of chemokines byperipheral blood mononuclear cells from allergic subje
/ AmJRespirCritCareMed1996 / Alveolar destruction in guinea pigs chronically exposed todiesel engine exhaust- A light microscopic and electron microscopic morphometry study
/ AmJRespirCritCareMed1997 / Diesel exhaustparticles enhance antigen-induced airway inflammation and local cytokine expression inmice taka (h) : 36 ~ 42
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