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논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2015.1
- 수록면
- 236 - 243 (8page)
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초록· 키워드
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Background: Chemotherapy-induced peripheral neuropathy is a major side effect of anti-cancer drugs, and our knowledge of its mechanisms is lacking. Several models for chemotherapy-induced neuropathy have been introduced. However, the outcomes of these models differ significantly among laboratories. Our object was to create a model of chemotherapy-induced neuropathy in rats with cancer.Methods: Female Sprague-Dawley rats were used. Mammary rat metastasis tumor (MRMT-1) cells were implanted subcutaneously in rats. Chemotherapy-induced peripheral neuropathy was induced by injection of cisplatin once a day for four days. The responses to mechanical and thermal stimuli were examined using von Frey filaments, acetone, and radiant heat. Results: Cisplatin (2 mg/kg/day) produced mechanical allodynia, while it did not induce cold allodynia or thermal hyperalgesia. This dose of cisplatin could work successfully against cancer. Body weight loss was not observed in cisplatin-treated rats, nor were other abnormal behaviors noted in the same rats.Conclusions: Repeated injection of intraperitoneal cisplatin induced peripheral neuropathic pain in rats. Thus, this type of rat model has broad applicability in studies related to searching for the mechanism of cisplatin-induced mechanical allodynia and agents for the treatment of neuropathic pain. (Korean J Pain 2015; 28: 236-243)
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등록된 정보가 없습니다.
참고문헌 (15)
참고문헌 신청
Al Moundhri MS / 2013 / The effect of curcumin on oxaliplatin and cisplatin neurotoxicity in rats: some behavioral, biochemical, and histopathological studies. / J Med Toxic
Authier N / 2003 / An animal model of nociceptive peripheral neuropathy following repeated cisplatin injections / Exp Neurol 182 : 12 ~ 20
Authier N / 2009 / Animal models of chemotherapy-evoked painful peripheral neuropathies / Neurotherapeutics 6 : 620 ~ 629
Cavaletti G / 1991 / Effects of repeated administration of low doses of cisplatin on the rat nervous system / Int J Tissue React 13 : 151 ~ 157
Choi Y / 1994 / Behavioral signs of ongoing pain and cold allodynia in a rat model of neuropathic pain / Pain 59 : 369 ~ 376
Authier N / 2003 / An animal model of nociceptive peripheral neuropathy following repeated cisplatin injections / Exp Neurol 182 : 12 ~ 20
Authier N / 2009 / Animal models of chemotherapy-evoked painful peripheral neuropathies / Neurotherapeutics 6 : 620 ~ 629
Cavaletti G / 1991 / Effects of repeated administration of low doses of cisplatin on the rat nervous system / Int J Tissue React 13 : 151 ~ 157
Choi Y / 1994 / Behavioral signs of ongoing pain and cold allodynia in a rat model of neuropathic pain / Pain 59 : 369 ~ 376
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