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학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
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논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2017.1
- 수록면
- 129 - 135 (7page)
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초록· 키워드
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The present study investigated the role of spinal glutamate recycling in the development of orofacial inflammatory pain or trigeminal neuropathic pain. Experiments were carried out on male Sprague–Dawley rats weighing between 230 and 280 g. Under anesthesia, a polyethylene tube was implanted in the atlanto-occipital membrane for intracisternal administration.
IL-1β-induced inflammation was employed as an orofacial acute inflammatory pain model. IL-1β (10 ng) was injected subcutaneously into one vibrissal pad. We used the trigeminal neuropathic pain animal model produced by chronic constriction injury of the infraorbital nerve. DL-threo-β -benzyloxyaspartate (TBOA) or methionine sulfoximine (MSO) was administered intracisternally to block the spinal glutamate transporter and the glutamine synthetase activity in astroglia. Intracisternal administration of TBOA produced mechanical allodynia in naïve rats, but it significantly attenuated mechanical allodynia in rats with interleukin (IL)-1 β-induced inflammatory pain or trigeminal neuropathic pain.
In contrast, intracisternal injection of MSO produced antiallodynic effects in rats treated with IL-1β or with infraorbital nerve injury. Intracisternal administration of MSO did not produce mechanical allodynia in naive rats. These results suggest that blockade of glutamate recycling induced pro-nociception in naïve rats, but it paradoxically resulted in anti-nociception in rats experiencing inflammatory or neuropathic pain. Moreover, blockade of glutamate reuptake could represent a new therapeutic target for the treatment of chronic pain conditions.
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참고문헌 (22)
참고문헌 신청
Ahn DK / 2004 /
Chiang CY / 2007 / Astroglial glutamate-glutamine shuttle is involved in central sensitization of nociceptive neurons in rat medullary dorsal horn / J Neurosci 27 : 9068 ~ 9
Danbolt NC / 2001 / Glutamate uptake / Prog Neurobiol 65 : 1 ~ 105
Fonseca LL / 2005 / Cultures of rat astrocytes challenged with a steady supply of glutamate : new model to study flux distribution in the glutamate-glutamine cycle / Glia 51
Hertz L / 2004 / Astrocytic control of glutamatergic activity : astrocytes as stars of the show / Trends Neurosci 27 : 735 ~ 743
Chiang CY / 2007 / Astroglial glutamate-glutamine shuttle is involved in central sensitization of nociceptive neurons in rat medullary dorsal horn / J Neurosci 27 : 9068 ~ 9
Danbolt NC / 2001 / Glutamate uptake / Prog Neurobiol 65 : 1 ~ 105
Fonseca LL / 2005 / Cultures of rat astrocytes challenged with a steady supply of glutamate : new model to study flux distribution in the glutamate-glutamine cycle / Glia 51
Hertz L / 2004 / Astrocytic control of glutamatergic activity : astrocytes as stars of the show / Trends Neurosci 27 : 735 ~ 743
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