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학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
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논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2015.1
- 수록면
- 364 - 370 (7page)
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초록· 키워드
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Background: Protease-activated receptor 2 (PAR-2) participates in various biological activities, including the regulation of epidermal barrier homeostasis, inflammation, pain perception, and melanosome transfer in the skin. Objective: To evaluate the basic physiological role of PAR-2 in skin.
Methods: We investigated PAR-2 expression in human epidermis, skin tumors, and cultured epidermal cells using western blot and immunohistochemical analysis. Additionally, we examined the effect of the PAR-2 agonist, SLIGRL-NH2, on cultured keratinocytes. Results: Strong PAR-2 immunoreactivity was observed in the granular layer of normal human skin and the acrosyringium of the eccrine sweat glands. In contrast, weak PAR-2 immunoreactivity was seen in the granular layer of callused skin and in the duct and gland cells of the eccrine sweat glands. Interestingly, PAR-2 immunoreactivity was very weak or absent in the tumor cells of squamous cell carcinoma (SCC) and syringoma. PAR-2 was detected in primary keratinocytes and SV-40T-transformed human epidermal keratinocytes (SV-HEKs), an immortalized keratinocyte cell line, but not in SCC12 cells. SV-HEKs that were fully differentiated following calcium treatment displayed higher PAR-2 expression than undifferentiated SV-HEKs. Treatment of cultured SV-HEKs with PAR-2 agonist increased loricrin and filaggrin expression, a terminal differentiation marker. Conclusion: Our data suggest that PAR-2 is associated with terminal differentiation of epidermis and eccrine sweat glands.
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참고문헌 (23)
참고문헌 신청
Ando H / 2010 / Keratinocytes in culture accumulate phagocytosed melanosomes in the perinuclear area / Pigment Cell Melanoma Res 23 : 129 ~ 133
Ando H / 2012 / Melanosomes are transferred from melanocytes to keratinocytes through the processes of packaging, release, uptake, and dispersion / J Invest Dermatol 132 : 1
Bovell DL / 2008 / Activation of chloride secretion via proteinase-activated receptor 2 in a human eccrine sweat gland cell line--NCL-SG3 / Exp Dermatol 17 : 505 ~ 511
Bovell DL / 2009 / PAR-2 receptor-induced effects on human eccrine sweat gland cells / J Med Invest 56 (Suppl) : 371 ~ 374
Demerjian M / 2008 / Acute modulations in permeability barrier function regulate epidermal cornification:role of caspase-14 and the protease-activated receptor type 2 / Am J
Ando H / 2012 / Melanosomes are transferred from melanocytes to keratinocytes through the processes of packaging, release, uptake, and dispersion / J Invest Dermatol 132 : 1
Bovell DL / 2008 / Activation of chloride secretion via proteinase-activated receptor 2 in a human eccrine sweat gland cell line--NCL-SG3 / Exp Dermatol 17 : 505 ~ 511
Bovell DL / 2009 / PAR-2 receptor-induced effects on human eccrine sweat gland cells / J Med Invest 56 (Suppl) : 371 ~ 374
Demerjian M / 2008 / Acute modulations in permeability barrier function regulate epidermal cornification:role of caspase-14 and the protease-activated receptor type 2 / Am J
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