지원사업
학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
커뮤니티
연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2016.12
- 수록면
- 319 - 325 (7page)
이용수
초록· 키워드
오류제보하기
Coagulation factor 2 receptor (F2R), also well-known as a protease-activated receptor 1 (PAR1), is the first known thrombin receptor and plays a critical role in transmitting thrombin-mediated activation of intracellular signaling in many types of cells. It has been known that bacterial infections lead to activation of coagulation systems, and recent studies suggest that PAR1 may be critically involved not only in mediating bacteria-induced detrimental coagulation, but also in innate immune and inflammatory responses. Community-acquired pneumonia, which is frequently caused by Streptococcus pneumoniae (S. pneumoniae), is characterized as an intra-alveolar coagulation and an interstitial neutrophilic inflammation. Recently, the role of PAR1 in regulating pneumococcal infections has been proposed. However, the role of PAR1 in pneumococcal infections has not been clearly understood yet. In this review, recent findings on the role of PAR1 in pneumococcal infections and possible underlying molecular mechanisms by which S. pneumoniae regulates PAR1-mediated immune and inflammatory responses will be discussed.
목차
INTRODUCTION
CONCLUSIONS
REFERENCES
참고문헌 (52)
참고문헌 신청
[학술지(정기간행물)] - Mizgerd JP / 2006 / Lung infection--a public health priority / PLoS Med 3 : e76 ~
[학술지(정기간행물)] - Niederman MS / 2001 / Guidelines for the management of community-acquired pneumonia. Current recommendations and antibiotic selection issues / Med Clin North Am 85 : 1493 ~ 1509
[학술지(정기간행물)] - Niederman MS / 2001 / Guidelines for the management of adults with community-acquired pneumonia. Diagnosis, assessment of severity, antimicrobial therapy, and prevention / Am J Respir Crit Care Med 163 : 1730 ~ 1754
[학술지(정기간행물)] - Tamayo E / 2016 / Streptococcus pyogenes Pneumonia in Adults: Clinical Presentation and Molecular Characterization of Isolates 2006-2015 / PLoS One 11 : e0152640 ~
[학술지(정기간행물)] - Dockrell DH / 2012 / Pneumococcal pneumonia : mechanisms of infection and resolution / Chest 142 : 482 ~ 491
[학술지(정기간행물)] - Niederman MS / 2001 / Guidelines for the management of community-acquired pneumonia. Current recommendations and antibiotic selection issues / Med Clin North Am 85 : 1493 ~ 1509
[학술지(정기간행물)] - Niederman MS / 2001 / Guidelines for the management of adults with community-acquired pneumonia. Diagnosis, assessment of severity, antimicrobial therapy, and prevention / Am J Respir Crit Care Med 163 : 1730 ~ 1754
[학술지(정기간행물)] - Tamayo E / 2016 / Streptococcus pyogenes Pneumonia in Adults: Clinical Presentation and Molecular Characterization of Isolates 2006-2015 / PLoS One 11 : e0152640 ~
[학술지(정기간행물)] - Dockrell DH / 2012 / Pneumococcal pneumonia : mechanisms of infection and resolution / Chest 142 : 482 ~ 491
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UCI(KEPA) : I410-ECN-0101-2017-475-001976710