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논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2018.1
- 수록면
- 47 - 53 (7page)
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Background: Connective tissue growth factor (CTGF) is a multifunctional cellular protein and playing a role as a central mediator in tissue remodeling and fibrosis. The physiological function of CTGF in psoriasis is unknown. Objective: The purpose of this study was to investigate the function of CTGF in psoriasis using the established imiquimod (IMQ)- induced psoriasis murine model and psoriasis patients. Methods: Anti-CTGF monoclonal antibody was applied to IMQ induced psoriasis mice and those skin were clinically, pathologically and immunologically analyzed. Additionally, CTGF expression was analyzes using skin samples and plasma from psoriasis patients. Results: CTGF expression was observed in the dermis from both IMQ-induced psoriatic mice and psoriasis patients. CTGF inhibition using an anti-CTGF antibody slightly worsened IMQ-induced dermatitis. In addition, the increase of CTGF showed tendency to suppress the psoriatic dermatitis through inhibition of suprabasal cells proliferation and macrophage infiltration in the skin. CTGF was also detected significantly higher in plasma from psoriasis patients comparing with healthy control. Conclusion: Our findings suggest that CTGF could contribute to the healing rather than the worsening of psoriasis skin lesions.
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참고문헌 (18)
참고문헌 신청
Leask A / 2004 / Insights into the molecular mechanism of chronic fibrosis: the role of connective tissue growth factor in scleroderma / J Invest Dermatol 122:1~6
Igarashi A / 1995 / Significant correlation between connective tissue growth factor gene expression and skin sclerosis in tissue sections from patients with systemic sclerosis / J Invest Dermatol 105:280~284
Takigawa M / 2003 / Role of CTGF/HCS24/ecogenin in skeletal growth control / J Cell Physiol 194:256~266
Nozawa K / 2009 / Connective tissue growth factor promotes articular damage by increased osteoclastogenesis in patients with rheumatoid arthritis / Arthritis Res Ther 11:R174
Nozawa K / 2013 / Inhibition of connective tissue growth factor ameliorates disease in a murine model of rheumatoid arthritis / Arthritis Rheum 65:1477~1486
Igarashi A / 1995 / Significant correlation between connective tissue growth factor gene expression and skin sclerosis in tissue sections from patients with systemic sclerosis / J Invest Dermatol 105:280~284
Takigawa M / 2003 / Role of CTGF/HCS24/ecogenin in skeletal growth control / J Cell Physiol 194:256~266
Nozawa K / 2009 / Connective tissue growth factor promotes articular damage by increased osteoclastogenesis in patients with rheumatoid arthritis / Arthritis Res Ther 11:R174
Nozawa K / 2013 / Inhibition of connective tissue growth factor ameliorates disease in a murine model of rheumatoid arthritis / Arthritis Rheum 65:1477~1486
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