지원사업
학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
커뮤니티
연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2020.1
- 수록면
- 162 - 168 (7page)
이용수
초록· 키워드
오류제보하기
Calcium is the most abundant stored mineral in the human body and is especially vital for bone health; thus, calcium deficiency can cause bone-related diseases, such as osteopenia and osteoporosis. However, a high concentration of serum calcium, which is commonly known as hypercalcemia, can also lead to weakened bones and, in severe cases, osteosarcoma. Therefore, it is necessary to maintain the concentration of calcium that is appropriate for bone biology. In the present study, we aimed to elucidate the effects of high concentration of calcium, approximately 2 folds the normal calcium level, on osteoblast differentiation. The CaCl2 treatment showed dose-dependent suppression of the alkaline phosphatase activity and mineralized nodule formation. Calcium showed cytotoxicity at an extremely high concentration, but a moderately high concentration of calcium that results in inhibitory effects to osteoblast differentiation showed no signs of cytotoxicity. We also confirmed that the CaCl2 treatment repressed the mRNA expression and protein abundance of various osteogenic genes and transcriptional factors. Considered together, these results indicate that a high concentration of calcium negatively regulates the osteoblast differentiation of C2C12 cells.
목차
등록된 정보가 없습니다.
참고문헌 (24)
참고문헌 신청
D. Burkard / 2018 / Effects of bone remodeling agents following teriparatide treatment / Osteoporosis International 29(6):1351~1357
David W Dempster / 2018 / Remodeling- and Modeling-Based Bone Formation With Teriparatide Versus Denosumab: A Longitudinal Analysis From Baseline to 3 Months in the AVA Study / Journal of Bone and Mineral Research 33(2):298~306
Brendan F Boyce / 2013 / Advances in osteoclast biology reveal potential new drug targets and new roles for osteoclasts / Journal of Bone and Mineral Research 28(4):711~722
Sengen Sun / 2008 / Bone disease drug discovery: examining the interactions between osteoblast and osteoclast / Expert Opinion on Therapeutic Targets 12(2):239~251
R. M. Francis / 2008 / What do we currently know about nutrition and bone health in relation to United Kingdom public health policy with particular reference to calcium and vitamin D? / British Journal of Nutrition 99(1):155~159
David W Dempster / 2018 / Remodeling- and Modeling-Based Bone Formation With Teriparatide Versus Denosumab: A Longitudinal Analysis From Baseline to 3 Months in the AVA Study / Journal of Bone and Mineral Research 33(2):298~306
Brendan F Boyce / 2013 / Advances in osteoclast biology reveal potential new drug targets and new roles for osteoclasts / Journal of Bone and Mineral Research 28(4):711~722
Sengen Sun / 2008 / Bone disease drug discovery: examining the interactions between osteoblast and osteoclast / Expert Opinion on Therapeutic Targets 12(2):239~251
R. M. Francis / 2008 / What do we currently know about nutrition and bone health in relation to United Kingdom public health policy with particular reference to calcium and vitamin D? / British Journal of Nutrition 99(1):155~159
함께 읽어보면 좋을 논문
논문 유사도에 따라 DBpia 가 추천하는 논문입니다. 함께 보면 좋을 연관 논문을 확인해보세요!
-
Calcium and Cardiovascular Disease
Endocrinology and Metabolism
2017 .01
-
The New Calcium Imaging Trend
Journal of Neurogastroenterology and Motility (JNM)
2016 .01
-
Coronary Calcification Is Reversely Related with Bone and Hair Calcium: The Relationship among Different Calcium Pools in Body
대한골대사학회지
2016 .01
-
Elevated Calcium after Acute Ischemic Stroke: Association with a Poor Short-Term Outcome and Long-Term Mortality
대한뇌졸중학회지
2015 .01
-
Letter to the Editor
Osteoporosis and Sarcopenia
2017 .01
-
칼슘 섭취 후 타액 내 칼슘 및 마그네슘 농도가 치아우식활성도에 미치는 영향
한국치위생학회지
2017 .01
-
Comparison of Calcium Intake Status by Region and Socioeconomic Status in Korea: The 2011-2013 Korea National Health and Nutrition Examination Survey
대한골대사학회지
2015 .01
-
Bioactive calcium phosphate materials and applications in bone regeneration
생체재료학회지
2019 .01
-
Recent nutritional trends of calcium and vitamin D in East Asia
Osteoporosis and Sarcopenia
2016 .01
-
Calcium and Vitamin D Supplementations: 2015 Position Statement of the Korean Society for Bone and Mineral Research
대한골대사학회지
2015 .01
-
Response to the Editor
Osteoporosis and Sarcopenia
2017 .01
-
Inadequate Dietary Calcium and Vitamin D Intake in Patients with Osteoporotic Fracture
대한골대사학회지
2016 .01
-
Skin Barrier and Calcium
Annals of Dermatology
2018 .01
-
Adherence to the Recommended Intake of Calcium and Colorectal Cancer Risk in the HEXA Study
Cancer Research and Treatment
2021 .01
-
Calcium Signaling in Salivary Secretion
Journal of Korean Dental Science
2017 .12
-
T-Type Calcium Channels Are Required to Maintain Viability of Neural Progenitor Cells
Biomolecules & Therapeutics(구 응용약물학회지)
2018 .01
-
Inhibitory Effects of PD98059, SB203580, and SP600125 on α- and δ-granule Release and Intracellular Ca2+ Levels in Human Platelets
대한의생명과학회지
2018 .09
-
Calcium homeostasis in diabetes mellitus
Journal of Veterinary Science
2017 .09
-
Effects of vitamin D deficiency and daily calcium intake on bone mineral density and osteoporosis in Korean postmenopausal woman
Obstetrics & Gynecology Science
2017 .01
이 논문의 저자 정보
최근 본 자료
댓글(0)
0