지원사업
학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
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연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2017.1
- 수록면
- 194 - 199 (6page)
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초록· 키워드
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Background: It has been reported that heat shock protein 70 (HSP70) and interleukin-8 (IL-8) play an important role in cells during the wound healing process. However, there has been no report on the effect of HSP70 and IL-8 on the blisters of burn patients. Objective: This study aimed to evaluate the serial quantitative changes of HSP70 and IL-8 in burn blisters.
Methods: Twenty-five burn patients were included, for a total of 36 cases: twenty cases on the first day, six cases on the second, five cases on the third, three cases on the fourth, and two cases on the fifth. A correlation analysis was performed to determine the relationship between the concentration of HSP70 and IL-8 and the length of the treatment period.
Results: The HSP70 concentration was the highest on the first day, after which it decreased down to near zero. Most HSP70 was generated during the first 12 hours after the burn accident. There was no correlation between the concentration of HSP70 on the first day and the length of the treatment period. No measurable concentration of IL-8 was detected before 5 hours, but the concentration started to increase after 11 hours. The peak value was measured on the fourth day. Conclusion: While HSP70 increased in the first few hours and decreased afterwards, IL-8 was produced after 11 hours and increased afterward in burn blister fluid. These findings provide new evidence on serial changes of inflammatory mediators in burn blister fluid.
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등록된 정보가 없습니다.
참고문헌 (24)
참고문헌 신청
Ashcroft GS / 2003 / Estrogen modulates cutaneous wound healing by downregulating macrophage migration inhibitory factor / J Clin Invest 111 : 1309 ~ 1318
Cleland H / 2012 / Thermal burns--assessment and acute management in the general practice setting / Aust Fam Physician 41 : 372 ~ 375
Fujita T / 2015 / Interleukin-8 induces DNA synthesis, migration and down-regulation of cleaved caspase-3 in cultured human gingival epithelial cells / J Periodontal Res 50
Giffard RG / 2008 / Regulation of apoptotic and inflammatory cell signaling in cerebral ischemia: the complex roles of heat shock protein 70 / Anesthesiology 109 : 339 ~ 348
Henderson B / 2010 / Integrating the cell stress response: a new view of molecular chaperones as immunological and physiological homeostatic regulators / Cell Biochem Funct 2
Cleland H / 2012 / Thermal burns--assessment and acute management in the general practice setting / Aust Fam Physician 41 : 372 ~ 375
Fujita T / 2015 / Interleukin-8 induces DNA synthesis, migration and down-regulation of cleaved caspase-3 in cultured human gingival epithelial cells / J Periodontal Res 50
Giffard RG / 2008 / Regulation of apoptotic and inflammatory cell signaling in cerebral ischemia: the complex roles of heat shock protein 70 / Anesthesiology 109 : 339 ~ 348
Henderson B / 2010 / Integrating the cell stress response: a new view of molecular chaperones as immunological and physiological homeostatic regulators / Cell Biochem Funct 2
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