지원사업
학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
커뮤니티
연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2021.12
- 수록면
- 460 - 466 (7page)
- DOI
- 10.3341/kjo.2021.0027
이용수
초록· 키워드
오류제보하기
Purpose: To investigate the induction pattern of various heat shock protein (HSP) in the optic nerve head after thermal stressusing transpupillary thermotherapy and to determine the dose-response relationship of thermal stress on the induction ofvarious HSP.
Methods: The 810-nm diode laser with 50-μm spot size was aimed to the center of optic nerve head of right eye of Norwaybrown rats. First, the various exposure powers (100, 120, 140 mW) were used with the same exposure duration, 60 seconds,to investigate power dosing effect. Second, the various exposure durations (1, 2, 3, and 5 minutes) were applied under constant100 mW laser power to investigate time dosing effect. Left eyes were served as controls. To quantify HSP expression,enucleation was performed at 24 hours after transpupillary thermotherapy. HSP 27 and αB-crystallin inductions in opticnerve head were examined with Western blot.
Results: All type of HSP was observed in normal state. After thermal injury, the expression of HSP 27 were increased, and theαB-crystallin were decreased.
Conclusions: Induction pattern of each HSP in the optic nerve head were different after thermal injury. Some HSPs were inducedor exhausted. Further research is needed on the characteristic functions and induction conditions of each HSP.
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등록된 정보가 없습니다.
참고문헌 (32)
참고문헌 신청
Tanaka Y / 1996 / Expression of 47kDa heat shock protein (HSP47) during development of mouse cornea / Exp Eye Res 63:383~393
Laios E / 1997 / Characterization of cold-induced heat shock protein expression in neonatal rat cardiomyocytes / Mol Cell Biochem 173:153~159
Tamm ER / 1996 / Human and monkey trabecular meshwork accumulate alpha B-crystallin in response to heat shock and oxidative stress / Invest Ophthalmol Vis Sci 37:2402~2413
Kitagawa K / 1991 / Hyperthermia-induced neuronal protection against ischemic injury in gerbils / J Cereb Blood Flow Metab 11:449~452
Caprioli J / 1996 / Hyperthermia and hypoxia increase tolerance of retinal ganglion cells to anoxia and excitotoxicity / Invest Ophthalmol Vis Sci 37:2376~2381
Laios E / 1997 / Characterization of cold-induced heat shock protein expression in neonatal rat cardiomyocytes / Mol Cell Biochem 173:153~159
Tamm ER / 1996 / Human and monkey trabecular meshwork accumulate alpha B-crystallin in response to heat shock and oxidative stress / Invest Ophthalmol Vis Sci 37:2402~2413
Kitagawa K / 1991 / Hyperthermia-induced neuronal protection against ischemic injury in gerbils / J Cereb Blood Flow Metab 11:449~452
Caprioli J / 1996 / Hyperthermia and hypoxia increase tolerance of retinal ganglion cells to anoxia and excitotoxicity / Invest Ophthalmol Vis Sci 37:2376~2381
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