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학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
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논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2008.1
- 수록면
- 184 - 189 (6page)
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초록· 키워드
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Background: Human skin is exposed to various environmental stresses, such as heat, cold, and ultraviolet (UV) radiation. Heat shock proteins (HSPs) induced by temperature elevations, as a physiologic response to mediate repair mechanisms and reduce cellular damage.
Objective: The purpose of this study was to investigate the induction of HSPs in human skin cells after UV exposure.
Methods: We performed immunoblotting using a specific monoclonal antibody to the HSP70 family, one of the best-conserved stress proteins in humans, with cultured normal human keratinocytes, A431 cells, human melanocytes, SK30 cells, and human dermal fibroblasts (HDF).
Results: Our results indicated that high expression of HSP70 in the unstressed state was noted in epidermal cells, including normal human keratinocytes, A431 cells, human melanocytes, and SK30 cells, but epidermal cells showed no additional up-regulation of HSP70 after UV irradiation. On the other hand, HDF expressed very small amounts of HSP70 at baseline, but significantly higher amounts of HSP70 after UV exposure.
Conclusion: These findings suggest that constitutive expression of HSP70 in epidermal cells may be an important mechanism for protection of the human epidermis from environmental stresses, such as sunlight exposure.
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등록된 정보가 없습니다.
참고문헌 (27)
참고문헌 신청
Beckmann RP / 1990 / Interaction of Hsp 70 with newly synthesized proteins: implications for protein folding and assembly / Science 248 : 850 ~ 854
Charveron M / 1995 / Cell stress and implications of the heat-shock response in skin / Cell Biol Toxicol 11 : 161 ~ 165
Craig EA / 1994 / Heat shock proteins and molecular chaperones: mediators of protein conformation and turnover in the cell / Cell 78 : 365 ~ 372
Frydman J / 1994 / Folding of nascent polypeptide chains in a high molecular mass assembly with molecular chaperones / Nature 370 : 111 ~ 117
Gething MJ / 1992 / Protein folding in the cell / Nature 355 : 33 ~ 45
Charveron M / 1995 / Cell stress and implications of the heat-shock response in skin / Cell Biol Toxicol 11 : 161 ~ 165
Craig EA / 1994 / Heat shock proteins and molecular chaperones: mediators of protein conformation and turnover in the cell / Cell 78 : 365 ~ 372
Frydman J / 1994 / Folding of nascent polypeptide chains in a high molecular mass assembly with molecular chaperones / Nature 370 : 111 ~ 117
Gething MJ / 1992 / Protein folding in the cell / Nature 355 : 33 ~ 45
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