지원사업
학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
커뮤니티
연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2015.1
- 수록면
- 128 - 132 (5page)
이용수
초록· 키워드
오류제보하기
Background: Psoriasis is a common chronic inflammatoryskin disease with a strong genetic basis. Cytokines such as tumornecrosis factor alpha (TNF-α), interleukins (ILs) such areIL-12 and IL-23, and interferon gamma (IFN-γ) are releasedfrom various inflammatory and resident cells, and have beenimplicated in the initiation/maintenance of inflammation.
Certain alleles of the aforementioned cytokines may be associatedwith disease susceptibility/severity. Objective: To investigatethe association of three common functional genepolymorphisms, namely TNF −308 G/A (rs1800629), IL12B(encoding the p40 subunit of IL-12/23) ＋1188 A/C (rs3212227),and IFNG ＋874 T/A (rs2430561) with psoriasis developmentand severity in Serbian patients. Methods: We genotyped130 patients with psoriasis (26 of whom also had psoriaticarthritis) and 259 controls; rs1800629 and rs3212227,and rs2430561, by real-time PCR assay. Results: The TNFGG genotype was detected at a higher frequency in patientswith psoriasis compared to control subjects (OR, 1.420; 95%CI, 0.870∼2.403) without statistical significance (p=0.191). Lack of the TNF G allele was associated with lowerpsoriasis severity (p=0.007). The IL12B AC genotype wasunderrepresented in the patients with psoriatic arthritis comparedto healthy subjects (OR, 0.308; 95% CI, 0.090∼1.057; p=0.049). The distribution of the rs2430561 alleleand genotype frequencies was similar between patients withpsoriasis and controls. Conclusion: Our study demonstratesan effect of the rs1800629 on psoriasis severity, and a marginalimpact of the rs3212227 on susceptibility to psoriaticarthritis. Collectively, our results obtained in a Serbian cohortexpand current knowledge regarding individual predispositionto psoriatic disease.
목차
등록된 정보가 없습니다.
참고문헌 (16)
참고문헌 신청
Baran W / 2008 / IFN-gamma promoter gene polymorphism in psoriasis vulgaris / Biomarkers 13 : 52 ~ 58
Basu M / 2012 / Gene-gene interaction and functional impact of polymorphisms on innate immune genes in controlling Plasmodium falciparum blood infection level / PLoS One 7 :
Cargill M / 2007 / A large-scale genetic association study confirms IL12B and leads to the identification of IL23R as psoriasis-risk genes / Am J Hum Genet 80 : 273 ~ 290
Craven NM / 2001 / Cytokine gene polymorphisms in psoriasis / Br J Dermatol 144 : 849 ~ 853
Eiris N / 2012 / Resequencing of the IL12B gene in psoriasis patients with the rs6887695/rs3212227 risk genotypes / Cytokine 60 : 27 ~ 29
Basu M / 2012 / Gene-gene interaction and functional impact of polymorphisms on innate immune genes in controlling Plasmodium falciparum blood infection level / PLoS One 7 :
Cargill M / 2007 / A large-scale genetic association study confirms IL12B and leads to the identification of IL23R as psoriasis-risk genes / Am J Hum Genet 80 : 273 ~ 290
Craven NM / 2001 / Cytokine gene polymorphisms in psoriasis / Br J Dermatol 144 : 849 ~ 853
Eiris N / 2012 / Resequencing of the IL12B gene in psoriasis patients with the rs6887695/rs3212227 risk genotypes / Cytokine 60 : 27 ~ 29
함께 읽어보면 좋을 논문
논문 유사도에 따라 DBpia 가 추천하는 논문입니다. 함께 보면 좋을 연관 논문을 확인해보세요!
-
Gene Expression Analysis of Inflammatory Cytokines in Korean Psoriatic Patients
Annals of Dermatology
2017 .01
-
Tissue and Serum Inflammatory Cytokine Levels in Korean Psoriasis Patients: A Comparison between Plaque and Guttate Psoriasis
Annals of Dermatology
2015 .01
-
Novel Mutations in IL-10 Promoter Region -377 (C>T), -150 (C>A) and their Association with Psoriasis in the Saudi Population
Asian Pacific journal of cancer prevention : APJCP
2015 .01
-
건선 연구에서 건선 피부 모델의 역할
대한건선학회지
2018 .01
-
Prevalence of Psoriasis in Korea: A Population-Based Epidemiological Study Using the Korean National Health Insurance Database
Annals of Dermatology
2017 .01
-
The Association between Psoriasis Area and Severity Index and Cardiovascular Risk Factor in Korean Psoriasis Patients
Annals of Dermatology
2016 .01
-
Validity of Diagnostic Codes for Identification of Psoriasis Patients in Korea
Annals of Dermatology
2020 .01
-
Relation between the Peripherofacial Psoriasis and Scalp Psoriasis
Annals of Dermatology
2016 .01
-
Psoriasis and Cardiovascular Disease: A Narrative Review
Korean Journal of Family Medicine
2021 .09
-
Comparison of Treatment Goals for Moderate-to-Severe Psoriasis between Korean Dermatologists and the European Consensus Report
Annals of Dermatology
2015 .01
-
Erythrodermic Psoriasis Treated with Golimumab: A Case Report
Annals of Dermatology
2015 .01
-
Genetic Risk Factors for Psoriasis in Turkish Population: −1540 C/A, −1512 Ins18, and +405 C/G Polymorphisms within the Vascular Endothelial Growth Factor Gene
Annals of Dermatology
2016 .01
-
Clinical Characteristics of Psoriasis for Initiation of Biologic Therapy: A Cluster Analysis
Annals of Dermatology
2023 .04
-
건선의 한방치험 3례 - 보골지추출물을 병행하여
한방안이비인후피부과학회지
2018 .01
-
I-Kappa-B-Zeta Regulates Interleukin-17A/Tumor Necrosis Factor-Alpha Mediated Synergistic Induction of Interleukin-19 and Interleukin-20 in Humane Keratinocytes
Annals of Dermatology
2021 .01
-
Histopathological Findings Are Associated with the Clinical Types of Psoriasis but Not with the Corresponding Lesional Psoriasis Severity Index
Annals of Dermatology
2015 .01
-
Comparison of Risk Allele Frequencies of Psoriasis-Associated Single-Nucleotide Polymorphisms in Different Population Groups
Annals of Dermatology
2023 .02
-
Real-World Outcomes of Adalimumab Treatment for Moderate and Severe Psoriasis in Korean Patients (RAPSODI Study)
Annals of Dermatology
2023 .04
-
건선의 치료 접근법에 대한 고찰 및 제언
한방안이비인후피부과학회지
2020 .01
이 논문의 저자 정보
최근 본 자료
댓글(0)
0