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학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
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연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2015.1
- 수록면
- 157 - 162 (6page)
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초록· 키워드
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Background: Dermatofibroma (DF) comprises a heterogeneousgroup of mesenchymal tumors, with fibroblastic andhistiocytic elements present in varying proportions. The cellof origin of DF has been investigated, but remains unclear.
Objective: The present study attempted to investigate the expressionof leukocyte-specific protein 1 (LSP1), a marker offibrocytes, in DF. Additionally, we evaluated the effectivenessof LSP1 in the differential diagnosis of DF from dermatofibrosarcomaprotuberans (DFSP). Methods: Immunohistochemicalstaining was performed on 20 cases of DF using antibodiesagainst LSP1, CD68, and factor XIIIa (FXIIIa). In addition,the expression of LSP1 and FXIIIa was evaluated in 20cases of DFSP. Results: Eighteen of 20 cases (90%) of DFstained positive for LSP1, with variation in the intensity ofexpression. CD68 was positive in 10 cases (50%), and FXIIIawas expressed in all cases of DF. There were differences betweenthe regional expression patterns of the three markersin individual tumors. In contrast, only 2 of 20 cases of DFSPexpressed LSP1, and none of DFSP cases stained positive forFXIIIa. Conclusion: The LSP1-positive cells in DF could potentiallybe fibrocyte-like cells. FXIIIa and CD68 expressionsuggests that dermal dendritic cells and histiocytes are constituentcells of DF. It is known that fibrocytes, dermal dendriticcells and histiocytes are all derived from CD14＋monocytes. Therefore, we suggest that DF may originatefrom CD14＋ monocytes. Additionally, the LSP1 immunohistochemicalstain could be useful in distinguishing betweenDF and DFSP.
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등록된 정보가 없습니다.
참고문헌 (19)
참고문헌 신청
Aiba S / 1998 / Phorbol 12-myristate 13-acetate can transform monocyte-derived dendritic cells to different cell types similar to those found in dermatofibroma. A possible in
Bellini A / 2007 / The role of the fibrocyte, a bone marrow-derived mesenchymal progenitor, in reactive and reparative fibroses / Lab Invest 87 : 858 ~ 870
Blakaj A / 2012 / Fibrocytes in health and disease / Fibrogenesis Tissue Repair 5 (Suppl 1) : S6 ~
Bucala R / 1994 / Circulating fibrocytes define a new leukocyte subpopulation that mediates tissue repair / Mol Med 1 : 71 ~ 81
Cerio R / 1989 / Histiocytoma cutis: a tumour of dermal dendrocytes (dermal dendrocytoma) / Br J Dermatol 120 : 197 ~ 206
Bellini A / 2007 / The role of the fibrocyte, a bone marrow-derived mesenchymal progenitor, in reactive and reparative fibroses / Lab Invest 87 : 858 ~ 870
Blakaj A / 2012 / Fibrocytes in health and disease / Fibrogenesis Tissue Repair 5 (Suppl 1) : S6 ~
Bucala R / 1994 / Circulating fibrocytes define a new leukocyte subpopulation that mediates tissue repair / Mol Med 1 : 71 ~ 81
Cerio R / 1989 / Histiocytoma cutis: a tumour of dermal dendrocytes (dermal dendrocytoma) / Br J Dermatol 120 : 197 ~ 206
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