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학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
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논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2015.1
- 수록면
- 275 - 282 (8page)
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초록· 키워드
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Background: The histologic characteristics of atopic dermatitis (AD) include perivascular edema and dilated tortuous vessels in the papillary dermis. A single nucleotide polymorphism (SNP) of the fms-related tyrosine kinase 4 (FLT4) gene is associated with AD. Objective: To investigate the associations between podoplanin (PDPN) gene SNPs and AD.
Methods: We genotyped 9 SNPs from 5 genes of 1,119 subjects (646 AD patients and 473 controls). We determined the promoter activity of 1 SNP (rs355022) by luciferase assay; this SNP was further investigated using 1,133 independent samples (441 AD patients and 692 controls). Results: The rs355022 and rs425187 SNPs and the C-A haplotype in the PDPN gene were significantly associated with intrinsic AD in the initial experiment. The rs355022 SNP significantly affected promoter activity in the luciferase assay. However, these results were not replicated in the replication study.
Conclusion: Two SNPs and the C-A haplotype in the PDPN gene are significantly associated with intrinsic AD; although, the results were confirmed by luciferase assay, they could not be replicated with independent samples. Nevertheless, further replication experiments should be performed in future studies.
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등록된 정보가 없습니다.
참고문헌 (23)
참고문헌 신청
Bell PA / 2002 / SNPstream UHT: ultra-high throughput SNP genotyping for pharmacogenomics and drug discovery / Biotechniques (Suppl) : 70 ~
Brown SJ / 2009 / Eczema genetics: current state of knowledge and future goals / J Invest Dermatol 129 : 543 ~ 552
Carlson CS / 2004 / Selecting a maximally informative set of single-nucleotide polymorphisms for association analyses using linkage disequilibrium / Am J Hum Genet 74 : 106
Denomme GA / 2005 / High-throughput multiplex single-nucleotide polymorphism analysis for red cell and platelet antigen genotypes / Transfusion 45 : 660 ~ 666
Durchdewald M / 2008 / Podoplanin is a novel fos target gene in skin carcinogenesis / Cancer Res 68 : 6877 ~ 6883
Brown SJ / 2009 / Eczema genetics: current state of knowledge and future goals / J Invest Dermatol 129 : 543 ~ 552
Carlson CS / 2004 / Selecting a maximally informative set of single-nucleotide polymorphisms for association analyses using linkage disequilibrium / Am J Hum Genet 74 : 106
Denomme GA / 2005 / High-throughput multiplex single-nucleotide polymorphism analysis for red cell and platelet antigen genotypes / Transfusion 45 : 660 ~ 666
Durchdewald M / 2008 / Podoplanin is a novel fos target gene in skin carcinogenesis / Cancer Res 68 : 6877 ~ 6883
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