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논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2018.1
- 수록면
- 364 - 371 (8page)
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Background: Genetic variations in calpain-10 and adiponectin gene are known to influence insulin secretion and resistance in type2 diabetes mellitus. Recently, several single nucleotide polymorphisms (SNPs) in calpain-10 and adiponectin gene have been reportedto be associated with type 2 diabetes and various metabolic derangements. We investigated the associations between specific calpain-10 and adiponectin gene polymorphisms and Korean type 2 diabetes patients. Methods: Overall, 249 type 2 diabetes patients and 131 non-diabetic control subjects were enrolled in this study. All the subjectswere genotyped for SNP-43 and -63 of calpain-10 gene and G276T and T45G frequencies of the adiponectin gene. The clinical characteristicsand measure of glucose metabolism were compared within these genotypes. Results: Among calpain-10 polymorphisms, SNP-63 T/T were more frequent in diabetes patients, and single SNP-63 increases thesusceptibility to type 2 diabetes. However, SNP-43 in calpain-10 and T45G and intron G276T in adiponectin gene were not significantlyassociated with diabetes, insulin resistance, nor insulin secretion. Conclusion: Variations in calpain-10, SNP-63 seems to increase the susceptibility to type 2 diabetes in Koreans while SNP-43 andadiponectin SNP-45, -276 are not associated with impaired glucose metabolism.
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참고문헌 (32)
참고문헌 신청
Kim WY / 2008 / Nutritional risk and metabolic syndrome in Korean type 2 diabetes mellitus / Asia Pac J Clin Nutr 17(Suppl 1):47~51
Stumvoll M / 2005 / Type 2 diabetes: principles of pathogenesis and therapy / Lancet 365:1333~1346
Kifagi C / 2008 / Association of calpain-10 polymorphisms with type 2 diabetes in the Tunisian population / Diabetes Metab 34:273~278
Evans JC / 2001 / Studies of association between the gene for calpain-10 and type 2 diabetes mellitus in the United Kingdom / Am J Hum Genet 69:544~552
Fingerlin TE / 2002 / Variation in three single nucleotide polymorphisms in the calpain-10 gene not associated with type 2 diabetes in a large Finnish cohort / Diabetes 51:1644~1648
Stumvoll M / 2005 / Type 2 diabetes: principles of pathogenesis and therapy / Lancet 365:1333~1346
Kifagi C / 2008 / Association of calpain-10 polymorphisms with type 2 diabetes in the Tunisian population / Diabetes Metab 34:273~278
Evans JC / 2001 / Studies of association between the gene for calpain-10 and type 2 diabetes mellitus in the United Kingdom / Am J Hum Genet 69:544~552
Fingerlin TE / 2002 / Variation in three single nucleotide polymorphisms in the calpain-10 gene not associated with type 2 diabetes in a large Finnish cohort / Diabetes 51:1644~1648
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