지원사업
학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
커뮤니티
연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2016.1
- 수록면
- 600 - 606 (7page)
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초록· 키워드
오류제보하기
Background: Stress is a known cause of hair loss in many species. Objective: In this study, we investigated the role of acute stress on hair growth using a rat model. Methods: Rats were immobilized for 24 hours and blood samples, and skin biopsies were taken. The effect of stress-serum on the in vitro proliferation of rat and human dermal papilla cells (hDPCs), as well as serum cortisol and corticotropin-releasing hormone levels, were measured. Mast cell staining was performed on the biopsied tissue. In addition, Western blot and quantitative real time polymerase chain reaction were used to assess mast cell tryptase and cytokine expression, respectively in rat skin biopsies. Results: Stress-serum treatment reduced significantly the number of viable hDPCs and arrested the cell cycle in the G1 phase, compared to serum from unrestrained rats (p＜0.05, respectively). Moreover, restrained rats had significantly higher levels of cortisol in serum than unrestrained rats (p＜0.01). Acute stress serum increased mast cell numbers and mast cell tryptase expression, as well as inducing interleukin (IL)-6 and IL-1β up-regulation.
Conclusion: These results suggest that acute stress also has an inhibitory effect on hair growth via cortisol release in addition to substance P-mast cell pathway.
목차
등록된 정보가 없습니다.
참고문헌 (29)
참고문헌 신청
Hadshiew IM. / 2004 / Burden of hair loss : stress and the underestimated psychosocial impact of telogen effluvium and androgenetic alopecia / J Invest Dermatol 123:455~457
Manolache L. / 2009 / Alopecia areata and relationship with stressful events in children / J Eur Acad Dermatol Venereol 23:107~109
Chu SY. / 2012 / Psychiatric comorbidities in patients with alopecia areata in Taiwan : a case-control study / Br J Dermatol 166:525~531
Manolache L. / 2007 / Stress in patients with alopecia areata and vitiligo / J Eur Acad Dermatol Venereol 21:921~928
Atefi N. / 2006 / Stressful life events and diffuse unexplained hair loss in women : a case-control study / Dermatology 213:44~45
Manolache L. / 2009 / Alopecia areata and relationship with stressful events in children / J Eur Acad Dermatol Venereol 23:107~109
Chu SY. / 2012 / Psychiatric comorbidities in patients with alopecia areata in Taiwan : a case-control study / Br J Dermatol 166:525~531
Manolache L. / 2007 / Stress in patients with alopecia areata and vitiligo / J Eur Acad Dermatol Venereol 21:921~928
Atefi N. / 2006 / Stressful life events and diffuse unexplained hair loss in women : a case-control study / Dermatology 213:44~45
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