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학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
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연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
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An autopsy for a fatal anaphylactic shock (AS) is not rare; however, postmortem diagnosis of anaphylaxis can be very challenging due to nonspecific macroscopic findings and absence of diagnostic tests except serum mast cell tryptase analysis. We tried to review the usefulness of histopathologic examination as an alternative method for the postmortem diagnosis of AS in this study. Immunohistochemical staining was carried out for detection of mast cells in 27 autopsy cases, including 7 AS cases, 5 false-positive cases, and 15 control cases at the National Forensic Service from January 2013 to May 2015, and the differences of mast cell counts and staining pattern were analyzed. The results revealed no differences in the number of mast cells among the three groups; however, a characteristic mast cell degranulation staining pattern was observed in the AS group and false-positive group. It can be conclusively inferred that the histopathologic examination could prove helpful in the postmortem diagnosis of AS, but it should serve as an ancillary option.
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참고문헌 (14)
참고문헌 신청
Pumphrey RS / 2000 / Postmortem findings after fatal anaphylactic reactions / J Clin Pathol 53:273~276
Edston E / 1998 / Beta-tryptase measurements post-mortem in anaphylactic deaths and in controls / Forensic Sci Int 93:135~142
Mayer DE / 2011 / Usefulness of post mortem determination of serum tryptase, histamine and diamine oxidase in the diagnosis of fatal anaphylaxis / Forensic Sci Int 212:96~101
Scarpelli MP / 2016 / Postmortem serum levels of IgE and mast cell tryptase in fatal asthma / Forensic Sci Int 269:113~118
Tamura N / 2017 / Amniotic fluid embolism:pathophysiology from the perspective of pathology / J Obstet Gynaecol Res 43:627~632
Edston E / 1998 / Beta-tryptase measurements post-mortem in anaphylactic deaths and in controls / Forensic Sci Int 93:135~142
Mayer DE / 2011 / Usefulness of post mortem determination of serum tryptase, histamine and diamine oxidase in the diagnosis of fatal anaphylaxis / Forensic Sci Int 212:96~101
Scarpelli MP / 2016 / Postmortem serum levels of IgE and mast cell tryptase in fatal asthma / Forensic Sci Int 269:113~118
Tamura N / 2017 / Amniotic fluid embolism:pathophysiology from the perspective of pathology / J Obstet Gynaecol Res 43:627~632
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