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학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
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논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 저널정보
- 대한소화관운동학회(현 대한소화기능성질환.운동학회) Journal of Neurogastroenterology and Motility (JNM) Journal of Neurogastroenterology and Motility (JNM) Vol.22 No.2
- 발행연도
- 2016.1
- 수록면
- 181 - 192 (12page)
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초록· 키워드
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Irritable bowel syndrome (IBS) is traditionally defined as a functional disorder since it lacks demonstrable pathological abnormalities. However, in recent years, low grade inflammatory infiltration, often rich in mast cells, in both the small and large bowel, has beenobserved in some patients with IBS. The close association of mast cells with major intestinal functions, such as epithelial secretionand permeability, neuroimmune interactions, visceral sensation, and peristalsis, makes researchers and gastroenterologists to focusattention on the key roles of mast cells in the pathogenesis of IBS. Numerous studies have been carried out to identify the mechanismsin the development, infiltration, activation, and degranulation of intestinal mast cells, as well as the actions of mast cells in theprocesses of mucosal barrier disruption, mucosal immune dysregulation, visceral hypersensitivity, dysmotility, and local and centralstress in IBS. Moreover, therapies targeting mast cells, such as mast cell stabilizers (cromoglycate and ketotifen) and antagonists ofhistamine and serotonin receptors, have been tried in IBS patients, and have partially exhibited considerable efficacy. This reviewfocuses on recent advances in the role of mast cells in IBS, with particular emphasis on bridging experimental data with clinicaltherapeutics for IBS patients.
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등록된 정보가 없습니다.
참고문헌 (104)
참고문헌 신청
Tadayuki Oshima / 2015 / Epidemiology of Functional Gastrointestinal Disorders in Japan and in the World / Journal of Neurogastroenterology and Motility (JNM) 21(3):320~329
Whorwell PJ / 2015 / IBS in 2014: developments in pathophysiology, diagnosis and management / Nat Rev Gastroenterol Hepatol 12:72~74
Ohman L / 2010 / Pathogenesis of IBS: role of inflammation, immunity and neuroimmune interactions / Nat Rev Gastroenterol Hepatol 7:163~173
Bischoff SC / 2007 / Human mast cells, bacteria, and intestinal immunity / Immunol Rev 217:329~337
O’Sullivan M / 2000 / Increased mast cells in the irritable bowel syndrome / Neurogastroenterol Motil 12:449~457
Whorwell PJ / 2015 / IBS in 2014: developments in pathophysiology, diagnosis and management / Nat Rev Gastroenterol Hepatol 12:72~74
Ohman L / 2010 / Pathogenesis of IBS: role of inflammation, immunity and neuroimmune interactions / Nat Rev Gastroenterol Hepatol 7:163~173
Bischoff SC / 2007 / Human mast cells, bacteria, and intestinal immunity / Immunol Rev 217:329~337
O’Sullivan M / 2000 / Increased mast cells in the irritable bowel syndrome / Neurogastroenterol Motil 12:449~457
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