지원사업
학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
커뮤니티
연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2019.1
- 수록면
- 154 - 163 (10page)
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초록· 키워드
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Background: Melanocytes are derived from neural crest, and various pigmentary disorders may accompany abnormalities in nerve system or develop following dermatome, suggesting that melanocyte and pigmentation may be closely related to neural factors. There are reports of Becker’s nevus (BN) showing linear and segmental configuration, suggesting the association of BN with nerve system. However, there are no studies regarding the expression of neuropeptides in BN. Objective: We investigated the expression of neuropeptides and innervation in BN. Methods: Polymerase chain reaction (PCR) array of 84 genes related to neuronal process was done. Among the genes with 10-fold or more increase in lesional, real-time PCR was performed for neuropeptide Y (NPY), galanin, neurotensin (NTS) and their receptors skin compared to normal skin. IHC stain was done to look for the expression of NPY, galanin, NTS and their receptors and the distribution of protein gene products (PGP) 9.5 immunoreactive nerve fibers. Results: PCR array revealed that 16 out of 84 genes related to neuronal process were increased by 10-fold or more in lesional skin. In real-time PCR of NPY, galanin, NTS and their receptors, statistically significant increase of NPY1R (p＜0.05) and marginally significant increase of NPY2R, GAL2R, and NTS2R (p＜0.1) was verified in lesional skin. In immunohistochemistry, NPY, NPY1R NPY2R, and NTS2R were highly expressed in lesional skin and increased PGP 9.5 immunoreactive linear nerve fibers were found in the epidermis of BN. Conclusion: NPY, galanin, NTS and their receptors and increased innervation may play a role in the pathogenesis of BN.
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등록된 정보가 없습니다.
참고문헌 (44)
참고문헌 신청
Becker SW / 1949 / Concurrent melanosis and hypertrichosis in distribution of nevus unius lateris / Arch Derm Syphilol 60:155~160
Glinick SE / 1983 / Becker's melanosis : associated abnormalities / J Am Acad Dermatol 9:509~514
Person JR / 1984 / Becker's nevus : an androgenmediated hyperplasia with increased androgen receptors / J Am Acad Dermatol 10:235~238
Stanford DG / 1996 / Dermal melanocytosis : a clinical spectrum / Australas J Dermatol 37:19~25
Zvulunov A / 1995 / Neurocutaneous syndromes associated with pigmentary skin lesions / J Am Acad Dermatol 32:915~935
Glinick SE / 1983 / Becker's melanosis : associated abnormalities / J Am Acad Dermatol 9:509~514
Person JR / 1984 / Becker's nevus : an androgenmediated hyperplasia with increased androgen receptors / J Am Acad Dermatol 10:235~238
Stanford DG / 1996 / Dermal melanocytosis : a clinical spectrum / Australas J Dermatol 37:19~25
Zvulunov A / 1995 / Neurocutaneous syndromes associated with pigmentary skin lesions / J Am Acad Dermatol 32:915~935
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